This is a proposal to continue to document the natural history of untreated and treated HIV infection in: 1) a group of 1637 men-who-have-sex-with-men (MSM) originally recruited in 1984-5; and 2) a group of 363 young Latino and African-American MSM recruited in 2002-3. The men are followed at three clinics (UCLA-Wilshire, UCLA/Harbor Research and Education Institute, and the Gay and Lesbian Center) with an extensive questionnaire eliciting behavioral, medical, and psychosocial information; physical examination; blood collection for concurrent evaluation of HIV status (HIV-negatives), viral load (HIV-positives), levels of T cells subsets, activation markers, and lipids; and assessment of HBV and HCV markers. Equal aliquots of serum, plasma, and cells are stored at the UCLA and the National Repository. The outcome status of 91% of the 1984-5 cohort is known, attributable in part to the outstanding commitment of the staff, most of whom have been with the UCLA center for more than ten years, and several for 20 years. The 2002-3 cohort members are in the process of completing their first follow-up visit. The UCLA site has demonstrated its scientific leadership through leadership roles in the MACS Executive Committee (Detels), chairmanship of the Malignancy (Martinez), and Neuropsychological (Miller) working groups, and leadership roles in flow cytometry (Jamieson), viral testing procedures (Young), and studies of resistance to HIV (Detels). UCLA investigators have been the lead authors on 65 MACS-wide and UCLA center-specific scientific publications since 1998. The objectives of the UCLA MACS Clinical Center are to: 1. Maintain the cohort of 2000 men recruited in 1984-85 and 2002-3 through 2009; 2. Collect specific clinical, behavioral, and psychosocial data and laboratory specimens to meet the scientific objectives of the MACS (see Part A submitted by the CAMACS); 3. Contribute scientific leadership for the overall MACS and extend scientific knowledge about the natural history of untreated and treated HIV disease; and, 4. Promote involvement in the MACS by qualified investigators at UCLA and other institutions. With the assistance of its Community Advisory Board and its outstanding staff, the UCLA Center of the MACS is committed to maintaining the same level of commitment, leadership and follow-up of the cohort through 2009.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01AI035040-16
Application #
7433883
Study Section
Special Emphasis Panel (ZAI1-EB-A (J1))
Program Officer
Roe, Joanad'Arc C
Project Start
1993-04-01
Project End
2009-04-24
Budget Start
2008-04-01
Budget End
2009-04-24
Support Year
16
Fiscal Year
2008
Total Cost
$3,972,360
Indirect Cost
Name
University of California Los Angeles
Department
Public Health & Prev Medicine
Type
Schools of Public Health
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
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Tibuakuu, Martin; Zhao, Di; Saxena, Ankita et al. (2018) Low thigh muscle mass is associated with coronary artery stenosis among HIV-infected and HIV-uninfected men: The Multicenter AIDS Cohort Study (MACS). J Cardiovasc Comput Tomogr 12:131-138
Maki, Pauline M; Rubin, Leah H; Springer, Gayle et al. (2018) Differences in Cognitive Function Between Women and Men With HIV. J Acquir Immune Defic Syndr 79:101-107
Dutta, Anupriya; Uno, Hajime; Lorenz, David R et al. (2018) Low T-cell subsets prior to development of virus-associated cancer in HIV-seronegative men who have sex with men. Cancer Causes Control 29:1131-1142
Martin, Maureen P; Naranbhai, Vivek; Shea, Patrick R et al. (2018) Killer cell immunoglobulin-like receptor 3DL1 variation modifies HLA-B*57 protection against HIV-1. J Clin Invest 128:1903-1912
Yanik, Elizabeth L; Hernández-Ramírez, Raúl U; Qin, Li et al. (2018) Brief Report: Cutaneous Melanoma Risk Among People With HIV in the United States and Canada. J Acquir Immune Defic Syndr 78:499-504
Mellor-Crummey, Lauren E; Lake, Jordan E; Wilhalme, Holly et al. (2018) A Comparison of the Liver Fat Score and CT Liver-to-Spleen Ratio as Predictors of Fatty Liver Disease by HIV Serostatus. J Clin Gastroenterol Hepatol 2:
Adland, Emily; Hill, Matilda; Lavandier, Nora et al. (2018) Differential Immunodominance Hierarchy of CD8+ T-Cell Responses in HLA-B*27:05- and -B*27:02-Mediated Control of HIV-1 Infection. J Virol 92:
Altekruse, Sean F; Shiels, Meredith S; Modur, Sharada P et al. (2018) Cancer burden attributable to cigarette smoking among HIV-infected people in North America. AIDS 32:513-521
Irwin, Michael R; Archer, Gemma; Olmstead, Richard et al. (2018) Increased risk of depression in non-depressed HIV infected men with sleep disturbance: Prospective findings from the Multicenter AIDS Cohort Study. EBioMedicine 36:454-460

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