The Study to help AIDS Research Effort (SHARE) studies the natural history of infection with human immuno deficiency virus, type 1 (HIV- 1). SHARE, along with similar sites in Chicago, Pittsburgh, and Los Angeles, forms the Multicenter AIDS Cohort Study (MACS). MACS participants, including 1447 enrolled in SHARE, have been followed semiannually since 1984 and have provided questionnaire data, physical exam data, laboratory data ( including HIV-1 serostatus and T - cell subset measurements), and a large repository of plasma, serum, cryopreserved peripheral blood mononuclear cells and other specimens. Evaluating and following the prevalent and incident cases of HIV-1 infection in the MACS including 584 in SHARE, has provided key insights into risk factor s for infection with HIV-1, progression of HIV-1 infection once it is established, host defense against HIV- 1, genetic factors affecting HIV-1 pathogenesis, and use and efficacy of different forms of therapy for HIV-1 infection and for opportunistic pathogens. SHARE and the MACS have made key contributions to defining the importance of the measurement of t- helper (CD4+) lymphocytes, plasma viral load, and immune activation as pathogenic and prognostic factors in HIV-1 infection. SHARE has also played a leading role in the MACS neuropsychological studies. The current project request the continuation of the follow up of the SHARE cohort from 1999 to 2003. Expected survival and enrollment of the HIV-1 infected cohort members through this time period is 89% Specific Aims of the renewal include defining the long-term efficacy and safety of newer highly active antiretroviral treatments (HAART) and new clinical outcomes associated with HAART - induced increases in survival (e.g, neurological and oncological diseases with long incubation periods); defining prognostic markers for people taking HAART; and following cohort members for full characterization of outcomes.
These aims can be addressed only with continued follow up of this extremely well-characterized cohort. Other studies that depend on such follow up, but will be carried out with collaborators rather than being directly addressed in this application, include virological and immunological mechanisms of HIV-1 pathogenesis, and laboratory correlates of disease progression or non-progression. The MACS should continue to play a leading role in studies designed to lead to better treatments and preventive vaccines for HIV-1 infection.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01AI035042-10
Application #
6534037
Study Section
Special Emphasis Panel (ZAI1-KWR-A (J1))
Program Officer
Roe, Joanad'Arc C
Project Start
1993-04-01
Project End
2004-03-31
Budget Start
2002-04-01
Budget End
2003-03-31
Support Year
10
Fiscal Year
2002
Total Cost
$2,228,493
Indirect Cost
Name
Johns Hopkins University
Department
Public Health & Prev Medicine
Type
Schools of Public Health
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Hanna, David B; Moon, Jee-Young; Haberlen, Sabina A et al. (2018) Carotid artery atherosclerosis is associated with mortality in HIV-positive women and men. AIDS 32:2393-2403
Levine, Andrew J; Martin, Eileen; Munro, Cynthia A et al. (2018) Intraindividual variability in neurocognitive performance: No influence due to HIV status or self-reported effort. J Clin Exp Neuropsychol 40:1044-1049
Robbins, Hilary A; Wiley, Dorothy J; Ho, Ken et al. (2018) Patterns of repeated anal cytology results among HIV-positive and HIV-negative men who have sex with men. Papillomavirus Res 5:143-149
Abraham, Alison G; Zhang, Long; Calkins, Keri et al. (2018) Vitamin D status and immune function reconstitution in HIV-infected men initiating therapy. AIDS 32:1069-1076
Price, Jennifer C; Seaberg, Eric C; Stosor, Valentina et al. (2018) Aspartate aminotransferase-to-platelet ratio index increases significantly 3 years prior to liver-related death in HIV-hepatitis-coinfected men. AIDS 32:2636-2638
AIDS-defining Cancer Project Working Group of IeDEA, COHERE in EuroCoord (2018) Non-Hodgkin lymphoma risk in adults living with HIV across five continents. AIDS 32:2777-2786
Wu, Minjie; Fatukasi, Omalara; Yang, Shaolin et al. (2018) HIV disease and diabetes interact to affect brain white matter hyperintensities and cognition. AIDS 32:1803-1810
Armstrong, Nicole M; Surkan, Pamela J; Treisman, Glenn J et al. (2018) Optimal metrics for identifying long term patterns of depression in older HIV-infected and HIV-uninfected men who have sex with men. Aging Ment Health :1-8
Elion, Richard A; Althoff, Keri N; Zhang, Jinbing et al. (2018) Recent Abacavir Use Increases Risk of Type 1 and Type 2 Myocardial Infarctions Among Adults With HIV. J Acquir Immune Defic Syndr 78:62-72
Grover, Surbhi; Desir, Fidel; Jing, Yuezhou et al. (2018) Reduced Cancer Survival Among Adults With HIV and AIDS-Defining Illnesses Despite No Difference in Cancer Stage at Diagnosis. J Acquir Immune Defic Syndr 79:421-429

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