Abstract

An estimated 80 million people are infected with Wuchereria bancrofti and Brugia malayi, mosquito-transmitted nematode parasites that cause deforming lymphatic filariasis in the tropics. There is clear evidence from animal studies that stage-specific immunity can develop to filarial microfilariae and to third stage infective larvae (L3). This ICIDR project represents an ambitious attempt to study immunity to filariasis in humans with a longitudinal study of carefully defined populations in a highly endemic region.
The SPECIFIC AIMS of this project are: 1. TO TEST THE HYPOTHESIS THAT HUMANS Develop PROTECTIVE IMMUNITY TO BANCROFTIAN FILARIASIS. 2. TO STUDY IMMUNITY TO MICROFILARIAE IN HUMANS. 3. TO IDENTIFY PARASITE ANTIGENS THAT MAY BE TARGETS OF PROTECTIVE IMMUNE RESPONSES TO L3 AND MICROFILARIAE OF WUCHERERIA BANCROFTI. 4. TO TEST THE HYPOTHESIS THAT MATERNAL INFECTION STATUS AFFECTS THE SUSCEPTIBILITY OF CHILDREN TO FILARIASIS.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01AI035855-05
Application #
2672327
Study Section
Special Emphasis Panel (SRC (89))
Project Start
1994-07-01
Project End
1999-08-31
Budget Start
1998-04-01
Budget End
1999-08-31
Support Year
5
Fiscal Year
1998
Total Cost
Indirect Cost

  Institution

Name
Barnes-Jewish Hospital
Department
Type
DUNS #
City
Saint Louis
State
MO
Country
United States
Zip Code
63110

  Publications

Abd Elaziz, Khaled M; El-Setouhy, Maged; Bradley, Mark H et al. (2013) Knowledge and practice related to compliance with mass drug administration during the Egyptian national filariasis elimination program. Am J Trop Med Hyg 89:260-4
Rao, Ramakrishna U; Huang, Yuefang; Bockarie, Moses J et al. (2009) A qPCR-based multiplex assay for the detection of Wuchereria bancrofti, Plasmodium falciparum and Plasmodium vivax DNA. Trans R Soc Trop Med Hyg 103:365-70
Fischer, Peter; Erickson, Sara M; Fischer, Kerstin et al. (2007) Persistence of Brugia malayi DNA in vector and non-vector mosquitoes: implications for xenomonitoring and transmission monitoring of lymphatic filariasis. Am J Trop Med Hyg 76:502-7
Farid, Hoda A; Morsy, Zakariya S; Helmy, Hanan et al. (2007) A critical appraisal of molecular xenomonitoring as a tool for assessing progress toward elimination of Lymphatic Filariasis. Am J Trop Med Hyg 77:593-600
El-Setouhy, Maged; Abd Elaziz, Khaled M; Helmy, Hanan et al. (2007) The effect of compliance on the impact of mass drug administration for elimination of lymphatic filariasis in Egypt. Am J Trop Med Hyg 77:1069-73
Helmy, Hanan; Weil, Gary J; Ellethy, Abou Sree T et al. (2006) Bancroftian filariasis: effect of repeated treatment with diethylcarbamazine and albendazole on microfilaraemia, antigenaemia and antifilarial antibodies. Trans R Soc Trop Med Hyg 100:656-62
Ramzy, Reda M R; El Setouhy, Maged; Helmy, Hanan et al. (2006) Effect of yearly mass drug administration with diethylcarbamazine and albendazole on bancroftian filariasis in Egypt: a comprehensive assessment. Lancet 367:992-9
Rao, Ramakrishna U; Atkinson, Laura J; Ramzy, Reda M R et al. (2006) A real-time PCR-based assay for detection of Wuchereria bancrofti DNA in blood and mosquitoes. Am J Trop Med Hyg 74:826-32
Rao, Ramakrishna U; Weil, Gary J; Fischer, Kerstin et al. (2006) Detection of Brugia parasite DNA in human blood by real-time PCR. J Clin Microbiol 44:3887-93
Farid, Hoda A; Hammad, Ragaa E; Hassan, Marah M et al. (2005) Effects of combined diethylcarbamazine and albendazole treatment of bancroftian filariasis on parasite uptake and development in Culex pipiens L. Am J Trop Med Hyg 73:108-14

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