Abstract

Taenia solium cysticerosis is increasingly recognized as an important public health hazard in both disease-endemic regions of the developing world and in areas with high immigrant populations in developing countries. T. solium has been recognized as a potentially eradicable parasite by WHO. However, no control strategy has been demonstrated to be effective and sustainable, excepting the improvement in public health that accompanies general development. Four independent yet closely related components will provide information required to shortcut development for porcine cysticerosis, and better understanding of the natural history of the disease, specifically in 3) T. solium transmission dynamics and 4) human Cysticerosis clinical evolution.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project--Cooperative Agreements (U01)
Project #
2U01AI035894-06
Application #
2875418
Study Section
Special Emphasis Panel (ZAI1-MSQ-M (M1))
Program Officer
Higgs, Elizabeth S
Project Start
1999-09-01
Project End
2004-08-31
Budget Start
1999-09-01
Budget End
2000-08-31
Support Year
6
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
Johns Hopkins University
Department
Public Health & Prev Medicine
Type
Schools of Public Health
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218

  Publications

Gonzales, Isidro; Miranda, J Jaime; Rodriguez, Silvia et al. (2015) Seizures, cysticercosis and rural-to-urban migration: the PERU MIGRANT study. Trop Med Int Health 20:546-52
Arriola, Carmen S; Gonzalez, Armando E; Gomez-Puerta, Luis A et al. (2014) New insights in cysticercosis transmission. PLoS Negl Trop Dis 8:e3247
Gavidia, Cesar M; Verastegui, Manuela R; Garcia, Hector H et al. (2013) Relationship between serum antibodies and Taenia solium larvae burden in pigs raised in field conditions. PLoS Negl Trop Dis 7:e2192
O'Neal, Seth E; Moyano, Luz M; Ayvar, Viterbo et al. (2012) Geographic correlation between tapeworm carriers and heavily infected cysticercotic pigs. PLoS Negl Trop Dis 6:e1953
Gavidia, Cesar M; Gonzalez, Armando E; Barron, Eduardo A et al. (2010) Evaluation of oxfendazole, praziquantel and albendazole against cystic echinococcosis: a randomized clinical trial in naturally infected sheep. PLoS Negl Trop Dis 4:e616
Uddin, Jasim; Gonzalez, Armando E; Gilman, Robert H et al. (2010) Mechanisms regulating monocyte CXCL8 secretion in neurocysticercosis and the effect of antiparasitic therapy. J Immunol 185:4478-84
Sheen, Patricia; Ferrer, Patricia; Gilman, Robert H et al. (2009) Effect of pyrazinamidase activity on pyrazinamide resistance in Mycobacterium tuberculosis. Tuberculosis (Edinb) 89:109-13
Lescano, Andres G; Garcia, Hector H; Gilman, Robert H et al. (2009) Taenia solium cysticercosis hotspots surrounding tapeworm carriers: clustering on human seroprevalence but not on seizures. PLoS Negl Trop Dis 3:e371
Villarán, Manuel V; Montano, Silvia M; Gonzalvez, Guillermo et al. (2009) Epilepsy and neurocysticercosis: an incidence study in a Peruvian rural population. Neuroepidemiology 33:25-31
Gavidia, Cesar M; Gonzalez, Armando E; Lopera, Luis et al. (2009) Evaluation of nitazoxanide and oxfendazole efficacy against cystic echinococcosis in naturally infected sheep. Am J Trop Med Hyg 80:367-72

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