Much that informs HIV disease and its treatment is derived from the developed world, mainly Caucasian populations. However, in many important respects HIV infection in Asia differs from other regions. The epidemiology of HIV infection is different, including large injecting drug use epidemics. Co-infection rates with hepatitis C and B are substantial. The natural history of HIV infection differs with faster progression rates and a different spectrum of opportunistic infections. There is emerging evidence that the pharmacology and toxicity of antiretroviral (ARV) treatments in Asian populations are different. Combined with differences such as ethnicities and economic development, and the coincident rapid expansion of ARV treatment access, the study of HIV disease and treatment in Asian populations is imperative. This study seeks to examine HIV disease natural history and treatment in Asia, and to assess differences with Caucasian populations. Specific studies will look at the efficacy and toxicity of ARV treatments. Studies of HIV and tuberculosis (TB), including HIV and TB treatment interactions, and immune reconstitution disease will be an important focus. The long-term effects of ARV treatments will be assessed, including trends in causes of death and comparisons with an age and behavior-matched HIV-negative group. The Asia-Pacific HIV Observational Database combines the TREAT Asia HIV Observational Database and the Australian HIV Observational Database, two established studies covering 39 sites in South, South East and East Asia and Australia, and following some 1750 individuals in Asia and 2329 in Australia. Both studies are observational, collecting demographic, treatment, disease outcome and toxicity data. A particular strength is having toxicity and outcome data collected and coded according to identical methods in Asia and Australia, allowing straightforward comparison of Asian and Caucasian populations. Both studies use an electronic transfer method of data collection that has demonstrated to be highly cost efficient while meeting stringent levels of data accuracy. Relevance: Asia (excluding China) is home to over one third of the world's population, and in 2005 some 7 million people living with HIV. It is known that in many important respects HIV epidemiology, natural history and ARV treatment outcomes differ in Asia compared with other regions. Simultaneously, ARV treatment is rapidly expanding. The Asia-Pacific HIV Observational Database aims to examine HIV disease natural history and treatment in Asia, and compare outcomes with Caucasian populations, principally in Australia, to inform optimal care and treatment for HIV disease in the region.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01AI069907-05
Application #
7911621
Study Section
Special Emphasis Panel (ZAI1-JB-A (J3))
Program Officer
Zimand, Lori B
Project Start
2006-07-15
Project End
2011-06-30
Budget Start
2010-07-01
Budget End
2011-06-30
Support Year
5
Fiscal Year
2010
Total Cost
$1,270,865
Indirect Cost
Name
Foundation for AIDS Research
Department
Type
DUNS #
152805909
City
New York
State
NY
Country
United States
Zip Code
10005
Somia, I Ketut Agus; Teeratakulpisarn, Nipat; Jeo, Wifanto S et al. (2018) Prevalence of and risk factors for anal high-risk HPV among HIV-negative and HIV-positive MSM and transgender women in three countries at South-East Asia. Medicine (Baltimore) 97:e9898
Huang, Robin; Petoumenos, Kathy; Gray, Richard T et al. (2018) National characteristics and trends in antiretroviral treatment in Australia can be accurately estimated using a large clinical cohort. J Clin Epidemiol 100:82-91
Hatleberg, C I; Ryom, L; d'Arminio Monforte, A et al. (2018) Association between exposure to antiretroviral drugs and the incidence of hypertension in HIV-positive persons: the Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) study. HIV Med 19:605-618
Prasitsuebsai, Wasana; Sethaputra, Chuenkamol; Lumbiganon, Pagakrong et al. (2018) Adherence to antiretroviral therapy, stigma and behavioral risk factors in HIV-infected adolescents in Asia. AIDS Care 30:727-733
IeDEA and COHERE Cohort Collaborations (2018) Global Trends in CD4 Cell Count at the Start of Antiretroviral Therapy: Collaborative Study of Treatment Programs. Clin Infect Dis 66:893-903
Giles, Michelle L; Achhra, Amit C; Abraham, Alison G et al. (2018) Sex-based differences in antiretroviral therapy initiation, switching and treatment interruptions: global overview from the International Epidemiologic Databases to Evaluate AIDS (IeDEA). J Int AIDS Soc 21:e25149
Hughes, Carly; Puhr, Rainer; Ojaimi, Samar et al. (2018) Human immunodeficiency virus-infected young people in Australia: data from the Australian HIV Observational Database. Intern Med J 48:1447-1456
Bartlett, Adam W; Mohamed, Thahira Jamal; Sudjaritruk, Tavitiya et al. (2018) Disease- and Treatment-Related Morbidity in Adolescents With Perinatal HIV Infection in Asia. Pediatr Infect Dis J :
Nimkar, S; Valvi, C; Kadam, D et al. (2018) Loss to follow-up and mortality among HIV-infected adolescents receiving antiretroviral therapy in Pune, India. HIV Med 19:395-402
Ryom, Lene; Lundgren, Jens D; El-Sadr, Wafaa et al. (2018) Cardiovascular disease and use of contemporary protease inhibitors: the D:A:D international prospective multicohort study. Lancet HIV 5:e291-e300

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