The IARC Monographs on the Evaluation of Carcinogenic Risks to Humans is an international evidence-based approach to carcinogen hazard identification initiated in 1971. The overall objective is to identify preventable causes o cancer. This is advanced by conducting authoritative evaluations of suspected carcinogens and disseminating the results through multiple media. Because a broad range of exposures may contribute to human cancer, carcinogen evaluations encompass environmental and occupational exposures, physical and biological agents, chemicals, complex mixtures and lifestyle factors. Almost 1000 agents have been evaluated to date, with 114 classified as carcinogenic and 352 as probably or possibly carcinogenic to humans. Agents are selected for evaluation based on evidence of human exposure, suspicion of carcinogenicity, and public health importance. Each IARC Monograph includes systematic reviews of the pertinent scientific literature and an evaluation of the weight of the evidence that an agent or exposure may be carcinogenic to humans. Monographs are developed by Working Groups selected on the principles of including the best-qualified experts and avoiding conflicts of interest. Nationa and international health agencies use the IARC Monographs as a trustworthy source of scientific information and as the scientific basis for their efforts to control cancer. The specifc aims of this project are to: organize at least 10 Monograph meetings to evaluate candidate carcinogenic agents of high global relevance and concern; convene Working Groups that are scientifically rigorous, respected, and free of conflict of interest; enhance the systematic search evaluation and documentation of scientific data for carcinogen evaluations; advance the use of mechanistic data in carcinogen evaluations; promote wide dissemination of evaluation results and engage in collaborations with national and international organizations to improve the science and practice of evaluating potential carcinogens. Important new initiatives in the proposed project period are to: expand the spectrum of mechanistic data considered in making evaluations to additional data streams, such as high-throughput test results; further systematize the review of mechanistic data according to key characteristics of carcinogens; introduce new working procedures and Web-based tools to enhance the documentation of the search for and evaluation of relevant literature on cancer in humans, cancer in experimental animals, and relevant mechanisms.
The IARC Monographs Programme identifies preventable causes of cancer by conducting authoritative, internationally-respected evaluations of suspected carcinogens, encompassing environmental and occupational exposures, physical and biological agents, chemicals, complex mixtures and lifestyle factors, by expert working groups; and by disseminating the results in IARC Monographs on the Evaluation of Carcinogenic Risks to Humans and through other media. This provides governments and health agencies worldwide with timely, trustworthy, authoritative scientific information to support actions to prevent cancer through control of exposure to known, probable, and possible carcinogens.
|Guha, Neela; Loomis, Dana; Guyton, Kathryn Z et al. (2017) Carcinogenicity of welding, molybdenum trioxide, and indium tin oxide. Lancet Oncol 18:581-582|
|Cichocki, Joseph A; Guyton, Kathryn Z; Guha, Neela et al. (2016) Target Organ Metabolism, Toxicity, and Mechanisms of Trichloroethylene and Perchloroethylene: Key Similarities, Differences, and Data Gaps. J Pharmacol Exp Ther 359:110-23|
|IARC Working Group on the Evaluation of Carcinogenic Risks to Humans (2016) Outdoor Air Pollution. IARC Monogr Eval Carcinog Risks Hum 109:9-444|
|Grosse, Yann; Loomis, Dana; Guyton, Kathryn Z et al. (2016) Carcinogenicity of some industrial chemicals. Lancet Oncol 17:419-20|
|IARC Working Group on the Evaluation of Carcinogenic Risks to Humans (2016) Some Drugs and Herbal Products. IARC Monogr Eval Carcinog Risks Hum 108:7-419|
|(2016) Polychlorinated Biphenyls and Polybrominated Biphenyls. IARC Monogr Eval Carcinog Risks Hum 107:9-500|
|Guyton, Kathryn Z; Loomis, Dana; Grosse, Yann et al. (2016) Carcinogenicity of pentachlorophenol and some related compounds. Lancet Oncol 17:1637-1638|
|Guha, Neela; Guyton, Kathryn Z; Loomis, Dana et al. (2016) Prioritizing Chemicals for Risk Assessment Using Chemoinformatics: Examples from the IARC Monographs on Pesticides. Environ Health Perspect 124:1823-1829|
|Loomis, Dana; Guyton, Kathryn Z; Grosse, Yann et al. (2016) Carcinogenicity of drinking coffee, mate, and very hot beverages. Lancet Oncol 17:877-878|
|Bouvard, Véronique; Loomis, Dana; Guyton, Kathryn Z et al. (2015) Carcinogenicity of consumption of red and processed meat. Lancet Oncol 16:1599-600|
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