Abstract

The overall objective of this proposal is to continue the ongoing Clinical Trial to compare the efficacy of Vitamin A (Retinol) versus a placebo in the prevention of basal cell carcinoma or cutaneous squamous cell carcinoma in participants diagnosed to have multiple actinic keratoses. Our research plan involves a multidisciplinary cancer research effort with the following specific aims: 1) To compare the incidence, frequency and time to development of subsequent basal or squamous cell skin cancers, 2) to measure the incidence, frequency and time to development of other cancers, 3) To determine the frequency of and motivate protocol compliance, 4) To determine the incidence, frequency, type and degree of toxicity.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01CA034256-07
Application #
3548323
Study Section
Special Emphasis Panel (SRC (15))
Project Start
1983-09-25
Project End
1990-11-30
Budget Start
1989-12-01
Budget End
1990-11-30
Support Year
7
Fiscal Year
1990
Total Cost
Indirect Cost

  Institution

Name
University of Arizona
Department
Type
Schools of Medicine
DUNS #
City
Tucson
State
AZ
Country
United States
Zip Code
85721

  Publications

Clouser, Mary C; Roe, Denise J; Foote, Janet A et al. (2010) Dose response of retinol and isotretinoin in the prevention of nonmelanoma skin cancer recurrence. Nutr Cancer 62:1058-66
Clouser, Mary C; Roe, Denise J; Foote, Janet A et al. (2009) Effect of non-steroidal anti-inflammatory drugs on non-melanoma skin cancer incidence in the SKICAP-AK trial. Pharmacoepidemiol Drug Saf 18:276-83
Cartmel, B; Moon, T E; Levine, N et al. (2000) Predictors of inactivation and reasons for participant inactivation during a skin cancer chemoprevention study. Cancer Epidemiol Biomarkers Prev 9:999-1002
Cartmel, B; Moon, T E; Levine, N (1999) Effects of long-term intake of retinol on selected clinical and laboratory indexes. Am J Clin Nutr 69:937-43
Moon, T E; Levine, N; Cartmel, B et al. (1997) Retinoids in prevention of skin cancer. Cancer Lett 114:203-5
Moon, T E; Levine, N; Cartmel, B et al. (1997) Effect of retinol in preventing squamous cell skin cancer in moderate-risk subjects: a randomized, double-blind, controlled trial. Southwest Skin Cancer Prevention Study Group. Cancer Epidemiol Biomarkers Prev 6:949-56
Levine, N; Moon, T E; Cartmel, B et al. (1997) Trial of retinol and isotretinoin in skin cancer prevention: a randomized, double-blind, controlled trial. Southwest Skin Cancer Prevention Study Group. Cancer Epidemiol Biomarkers Prev 6:957-61
Moon, T E; Levine, N; Cartmel, B et al. (1995) Design and recruitment for retinoid skin cancer prevention (SKICAP) trials. The Southwest Skin Cancer Prevention Study Group. Cancer Epidemiol Biomarkers Prev 4:661-9
Gritz, E R; Moon, T E (1992) The new cancer prevention and control. Cancer Epidemiol Biomarkers Prev 1:163-5
Moon, T E (1991) Planning the analysis of a breast cancer prevention trial. Prev Med 20:109-18

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