The proposed research will investigate the role of Beta-carotene as a lung cancer preventive agent. A high risk cohort of men occupationally exposed to asbestos and a selected group of hospital patients with abnormal sputum cytopathology will be used for a randomized clinical trial of Beta-carotene versus placebo. Bronchial epithelial changes, evaluated by repeated sputum cytology, will be used as the measure of response to the chemopreventive agent. Serum levels of Beta-carotene will be studied with respect to the degree of sputum metaplasia or dysplasia found at initial examination and with respect to bronchial epithelial changes throughout the clinical trial.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01CA034290-03
Application #
3548337
Study Section
(SSS)
Project Start
1984-09-30
Project End
1989-08-31
Budget Start
1986-09-01
Budget End
1987-08-31
Support Year
3
Fiscal Year
1986
Total Cost
Indirect Cost
Name
University of Texas Health Center at Tyler
Department
Type
Hospitals
DUNS #
City
Tyler
State
TX
Country
United States
Zip Code
75708
McLarty, J W; Holiday, D B; Girard, W M et al. (1995) Beta-Carotene, vitamin A, and lung cancer chemoprevention: results of an intermediate endpoint study. Am J Clin Nutr 62:1431S-1438S
Holiday, D B; McLarty, J W; Yanagihara, R H et al. (1995) Two biochemical markers effectively used to separate smokeless tobacco users from smokers and nonusers. South Med J 88:1107-13
Holiday, D B; McLarty, J W; Farley, M L et al. (1995) Sputum cytology within and across laboratories. A reliability study. Acta Cytol 39:195-206
Holiday, D B; McLarty, J W (1994) Identifying disagreement in ordinal ratings within a fixed panel of cytotechnologists. Anal Quant Cytol Histol 16:381-92