The Metropolitan New York Registry of Breast Cancer Families is one of six international sites comprising the Cooperative Family Registry for Breast Cancer Studies (CFRBCS). The goal of the CFRBCS has been the development of a comprehensive resource for interdisciplinary genetic epidemiology studies addressing breast cancer risk and prognostic factors. The NY Registry has recruited 1102 families and collected biospecimens, pedigree and epidemiologic data on family members. In this competing continuation, the goals are to: recruit additional families of African American, Hispanic and Asian Heritage; increase the number of relatives participating per family complete collection of biospecimens, including tumor tissue blocks, and data from consented participants; conduct comprehensive follow-up 5 years after enrollment including data on current cancer status of all relatives in the family pedigree; continue biannual mailings of newsletters and invitations to educational, community-based seminars; maintain the integrity of the database, create new databases as needed, update data files and submit data to the CFRBCS Informatics Support Center; maintain biospecimens repository; process and bank additional biospecimens from newly recruited families complete retrieval of pathology materials. These goals are necessary for the NY Registry to provide the resources needed for ongoing CFRBCS research, collaborative studies with external scientists, and for the extensive multi-disciplinary research modules. Included in this renewal application. Members of the NY Registry team will take a leadership role in three of the research modules: Module 2-DNA repair genes and breast cancer, Module 9-Genetic modifiers of BRCA penetrance in Ashkenazim and Module 10-Module-Estrogen-gene variants and breast cancer. The NY Registry will also contribute resources and expertise to the other research modules proposed by CFRBCS colleagues: Module 1- Systematic follow-up study, Module 3-BRCA + mutations in minority families, Module 4-Environmental modifiers of breast cancer risk in carriers of BRCA mutations, Module 5-Prognosis and pathologic characteristics of heritable breast cancer, Module 6-Cancer screening and prevention in BRCA1 and BRCA2 mutation carriers, Module 7- Participation in a family based cancer registry. behavioral and social outcomes, Module 8-Outcomes of genetic testing among Ashkenazim families, Module 11-identification of novel genes involved in breast cancer susceptibility, Module 12-Mammographic densities and familial breast cancer, and Module 13-Penetrance and prevalence of BRCA1/2 mutations in the CFRBCS. Renewal of the CFRBCS will enable our collaborators team to expanded and enhanced our unique resources for multi-disciplinary research with the potential for identifying new avenues for prevention, detection and treatment of breast cancer.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01CA069398-12
Application #
6895597
Study Section
Special Emphasis Panel (ZCA1-SRRB-Y (O2))
Program Officer
Seminara, Daniela
Project Start
1995-09-30
Project End
2006-06-30
Budget Start
2005-04-01
Budget End
2006-06-30
Support Year
12
Fiscal Year
2005
Total Cost
$1,058,409
Indirect Cost
Name
Columbia University (N.Y.)
Department
Public Health & Prev Medicine
Type
Schools of Public Health
DUNS #
621889815
City
New York
State
NY
Country
United States
Zip Code
10032
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Dite, Gillian S; MacInnis, Robert J; Bickerstaffe, Adrian et al. (2016) Breast Cancer Risk Prediction Using Clinical Models and 77 Independent Risk-Associated SNPs for Women Aged Under 50 Years: Australian Breast Cancer Family Registry. Cancer Epidemiol Biomarkers Prev 25:359-65
Tehranifar, Parisa; Wu, Hui-Chen; Shriver, Tom et al. (2015) Validation of family cancer history data in high-risk families: the influence of cancer site, ethnicity, kinship degree, and multiple family reporters. Am J Epidemiol 181:204-12
Rebbeck, Timothy R (see original citation for additional authors) (2015) Association of type and location of BRCA1 and BRCA2 mutations with risk of breast and ovarian cancer. JAMA 313:1347-61
Antoniou, Antonis C; Casadei, Silvia; Heikkinen, Tuomas et al. (2014) Breast-cancer risk in families with mutations in PALB2. N Engl J Med 371:497-506
Delgado-Cruzata, Lissette; Wu, Hui-Chen; Liao, Yuyan et al. (2014) Differences in DNA methylation by extent of breast cancer family history in unaffected women. Epigenetics 9:243-8
Work, Meghan E; Reimers, Laura L; Quante, Anne S et al. (2014) Changes in mammographic density over time in breast cancer cases and women at high risk for breast cancer. Int J Cancer 135:1740-4
Ferris, J S; Daly, M B; Buys, S S et al. (2014) Oral contraceptive and reproductive risk factors for ovarian cancer within sisters in the breast cancer family registry. Br J Cancer 110:1074-80
Dite, Gillian S; Mahmoodi, Maryam; Bickerstaffe, Adrian et al. (2013) Using SNP genotypes to improve the discrimination of a simple breast cancer risk prediction model. Breast Cancer Res Treat 139:887-96
Gracia-Aznarez, Francisco Javier; Fernandez, Victoria; Pita, Guillermo et al. (2013) Whole exome sequencing suggests much of non-BRCA1/BRCA2 familial breast cancer is due to moderate and low penetrance susceptibility alleles. PLoS One 8:e55681

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