In the four years that the Cooperative Family Registry for Breast Cancer Studies (CFRBCS) has been funded, the six sites have accrued the world's largest population of women and families at genetic risk to develop breast and ovarian cancer. Subjects have been recruited from both population-based and clinic-based sites in the U.S., Canada and Australia. Biospecimens and extensive data have been collected in a uniform fashion and systematic follow-up is ongoing. The Utah site of the CFRBCS (termed interchangeably by the Utah Family Registry or the High Risk Breast genes. The Utah Family Registry, along with a unified CFRBCS, is uniquely able to conduct research in the genetic epidemiology of breast cancer. The multi-center nature and centralized database allow us to study to study a large cohort rapidly. The collaborative relationships developed during the formation of the CFRBCS infrastructure have facilitated agreement about research methods and data collection, placing us in strong position to achieve our research goals in a timely and cost-effective manner. This application contains four separate sections. First, we describe the progress of the Utah Family Registry and our plan to enhance the value of the CFRBCS for research studies conducted both by the CFRBCS and by outside investigators. This will be accomplished by expanding the number of mutation-carrying subjects enrolled and by providing breast and ovarian epithelial cell lines from subjects with breast cancer predisposition genes. We also describe our plans to collaborate in research conducted by each of the other CFRBCS sites. The final overview and progress report of the CFRBCS and coordinated by the Utah Family Registry. These include a definitive study of the prognosis and pathologic characteristics of breast cancers occurring in women will germline mutations in BRCA1 and BRCA2 genes, and a study of the screening and prevention practices and efficacy in mutation carriers.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project--Cooperative Agreements (U01)
Project #
2U01CA069446-07
Application #
6288336
Study Section
Special Emphasis Panel (ZCA1-SRRB-Y (O2))
Program Officer
Seminara, Daniela
Project Start
1995-09-30
Project End
2005-11-30
Budget Start
2001-02-22
Budget End
2001-11-30
Support Year
7
Fiscal Year
2001
Total Cost
$612,245
Indirect Cost
Name
University of Utah
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
City
Salt Lake City
State
UT
Country
United States
Zip Code
84112
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Dite, Gillian S; MacInnis, Robert J; Bickerstaffe, Adrian et al. (2016) Breast Cancer Risk Prediction Using Clinical Models and 77 Independent Risk-Associated SNPs for Women Aged Under 50 Years: Australian Breast Cancer Family Registry. Cancer Epidemiol Biomarkers Prev 25:359-65
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Piccolo, Stephen R; Andrulis, Irene L; Cohen, Adam L et al. (2015) Gene-expression patterns in peripheral blood classify familial breast cancer susceptibility. BMC Med Genomics 8:72
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Ferris, J S; Daly, M B; Buys, S S et al. (2014) Oral contraceptive and reproductive risk factors for ovarian cancer within sisters in the breast cancer family registry. Br J Cancer 110:1074-80
Dite, Gillian S; Mahmoodi, Maryam; Bickerstaffe, Adrian et al. (2013) Using SNP genotypes to improve the discrimination of a simple breast cancer risk prediction model. Breast Cancer Res Treat 139:887-96
Gracia-Aznarez, Francisco Javier; Fernandez, Victoria; Pita, Guillermo et al. (2013) Whole exome sequencing suggests much of non-BRCA1/BRCA2 familial breast cancer is due to moderate and low penetrance susceptibility alleles. PLoS One 8:e55681
Gaudet, Mia M; Kuchenbaecker, Karoline B; Vijai, Joseph et al. (2013) Identification of a BRCA2-specific modifier locus at 6p24 related to breast cancer risk. PLoS Genet 9:e1003173
Mocci, Evelina; Milne, Roger L; Méndez-Villamil, Elena Yuste et al. (2013) Risk of pancreatic cancer in breast cancer families from the breast cancer family registry. Cancer Epidemiol Biomarkers Prev 22:803-11

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