Abstract

AIDS related malignancies are likely to be a permanent part of the clinical landscape. Although improved anti-retroviral therapy has extended the survival of AIDS patients it does not completely restore immunocompetence. We (the University of Miami and University of Alabama at Birmingham) have outlined our plan for participation in the AIDS Malignancies Consortium including patient recruitment, novel therapies and complementary studies. Our program in viral oncology combines clinical and basic research with physician scientist training. Our research focuses on the role of gamma herpesviruses in AIDS malignancies and how their presence may be exploited therapeutically and diagnostically. The co-leaders of our project have expertise in Kaposi's sarcoma, lymphoma, or biology, immunotherapy and clinical trials management. The development of treatment strategies for AIDS neoplasms will benefit others at risk for opportunistic cancers (the elderly, children with hereditary immunodeficiencies and organ transplant recipients). It is our belief that the AMC exists not simply to perform clinical trials, but as leader in translational biomedical science. Our application reflects this philosophy.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01CA070058-08
Application #
6522360
Study Section
Special Emphasis Panel (ZCA1-SRRB-Y (M1))
Program Officer
Bhatia, Kishor
Project Start
1995-09-30
Project End
2004-07-31
Budget Start
2002-09-06
Budget End
2003-07-31
Support Year
8
Fiscal Year
2002
Total Cost
$227,600
Indirect Cost

  Institution

Name
University of Miami School of Medicine
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
City
Miami
State
FL
Country
United States
Zip Code
33146

  Publications

Lin, Lan; Lee, Jeannette Y; Kaplan, Lawrence D et al. (2009) Effects of chemotherapy in AIDS-associated non-Hodgkin's lymphoma on Kaposi's sarcoma herpesvirus DNA in blood. J Clin Oncol 27:2496-502
Ratner, Lee; Harrington, William; Feng, Xuan et al. (2009) Human T cell leukemia virus reactivation with progression of adult T-cell leukemia-lymphoma. PLoS One 4:e4420
Xia, Tianli; O'Hara, Andrea; Araujo, Iguaracyra et al. (2008) EBV microRNAs in primary lymphomas and targeting of CXCL-11 by ebv-mir-BHRF1-3. Cancer Res 68:1436-42
Gualco, Gabriela; Bacchi, Carlos E (2008) B-cell and T-cell lymphomas of the breast: clinical--pathological features of 53 cases. Int J Surg Pathol 16:407-13
Gualco, Gabriela; van den Berg, Anke; Koopmans, Sicco et al. (2008) Autoimmune lymphoproliferative syndrome in a patient with a new minimal deletion in the death domain of the FAS gene. Hum Pathol 39:137-41
Brinker, Brett T; Krown, Susan E; Lee, Jeannette Y et al. (2008) Phase 1/2 trial of BMS-275291 in patients with human immunodeficiency virus-related Kaposi sarcoma: a multicenter trial of the AIDS Malignancy Consortium. Cancer 112:1083-8
Sampaio, Julio; Brites, Carlos; Araujo, Iguaracyra et al. (2007) AIDS related malignancies in Brazil. Curr Opin Oncol 19:476-8
Ramos, Juan Carlos; Ruiz Jr, Phillip; Ratner, Lee et al. (2007) IRF-4 and c-Rel expression in antiviral-resistant adult T-cell leukemia/lymphoma. Blood 109:3060-8
Dezube, Bruce J; Krown, Susan E; Lee, Jeannette Y et al. (2006) Randomized phase II trial of matrix metalloproteinase inhibitor COL-3 in AIDS-related Kaposi's sarcoma: an AIDS Malignancy Consortium Study. J Clin Oncol 24:1389-94
Kaplan, Lawrence D; Lee, Jeannette Y; Ambinder, Richard F et al. (2005) Rituximab does not improve clinical outcome in a randomized phase 3 trial of CHOP with or without rituximab in patients with HIV-associated non-Hodgkin lymphoma: AIDS-Malignancies Consortium Trial 010. Blood 106:1538-43

Showing the most recent 10 out of 16 publications