Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01CA072162-03
Application #
6103299
Study Section
Project Start
1998-09-01
Project End
1999-08-31
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
3
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Duke University
Department
Type
DUNS #
071723621
City
Durham
State
NC
Country
United States
Zip Code
27705
Nair, Smita K; Morse, Michael; Boczkowski, David et al. (2002) Induction of tumor-specific cytotoxic T lymphocytes in cancer patients by autologous tumor RNA-transfected dendritic cells. Ann Surg 235:540-9
Morse, Michael A; Nair, Smita K; Boczkowski, David et al. (2002) The feasibility and safety of immunotherapy with dendritic cells loaded with CEA mRNA following neoadjuvant chemoradiotherapy and resection of pancreatic cancer. Int J Gastrointest Cancer 32:1-6
Morse, Michael A; Lyerly, H Kim (2002) DNA and RNA modified dendritic cell vaccines. World J Surg 26:819-25
Lyerly, H K; Morse, M A; Clay, T M (2001) Surrogate markers of effective anti-tumor immunity. Ann Surg Oncol 8:190-1
Hobeika, A C; Clay, T M; Mosca, P J et al. (2001) Quantitating therapeutically relevant T-cell responses to cancer vaccines. Crit Rev Immunol 21:287-97
Morse, M A; Clay, T M; Hobeika, A C et al. (2001) Surrogate markers of response to cancer immunotherapy. Expert Opin Biol Ther 1:153-8
Nair, S K; Hull, S; Coleman, D et al. (1999) Induction of carcinoembryonic antigen (CEA)-specific cytotoxic T-lymphocyte responses in vitro using autologous dendritic cells loaded with CEA peptide or CEA RNA in patients with metastatic malignancies expressing CEA. Int J Cancer 82:121-4
Morse, M A; Coleman, R E; Akabani, G et al. (1999) Migration of human dendritic cells after injection in patients with metastatic malignancies. Cancer Res 59:56-8
Morse, M A; Vredenburgh, J J; Lyerly, H K (1999) A comparative study of the generation of dendritic cells from mobilized peripheral blood progenitor cells of patients undergoing high-dose chemotherapy. J Hematother Stem Cell Res 8:577-84
Morse, M A; Deng, Y; Coleman, D et al. (1999) A Phase I study of active immunotherapy with carcinoembryonic antigen peptide (CAP-1)-pulsed, autologous human cultured dendritic cells in patients with metastatic malignancies expressing carcinoembryonic antigen. Clin Cancer Res 5:1331-8