The Environmental Determinants of Diabetes in the Young (TEDDY), a multicenter prospective cohort study, was initiated in 2003 to identify environmental factors that trigger or protect against the development of islet autoimmunity and type 1 diabetes (T1D). A successful study outcome should allow better understanding of the etiology and pathogenesis of T1D and the development of new strategies to prevent, delay, or reverse the disease. Newborns are screened by HLA-DR,DQ genotyping to identify those at increased risk for T1D. Eligible children are followed four times per year until 4 years of age and twice a year thereafter until 15 years of age.
The specific aims of the GA/FL Clinical Center renewal application are to: 1) Complete our contribution to the HLA-DR,DQ screening of 361,000 newborns and enrollment of 7,800 high-risk infants into intensive prospective follow-up to achieve the overall TEDDY goals, 2) Refine strategies to retain subjects enrolled in the follow-up and collect all planned biological specimens and epidemiological data according to the standard protocol including close monitoring of performance and sample/data quality, 3) Ascertain prospectively development of islet autoantibodies and clinical T1D in the study subjects, 4) Perform planned laboratory tests at appropriate times using a nested case-control study design to answer specific scientific questions and hypotheses pertinent to the TEDDY study goals, 5) Analyze and publish laboratory and epidemiological data in collaboration with other TEDDY clinical centers and the Data Coordinating Center, 6) Guide the ongoing TEDDY project by participation of the Clinical Center investigators and staff in work of the study Steering Committee and sub-committees. These proposed activities are essential to achieve the following long-term scientific goals: 1) To identify environmental factors (infectious, dietary, psychosocial factors, toxins, allergens, etc) that trigger or protect against the development of islet autoantibodies or T1 D. 2) To assess potential gene-environment interactions to improve identification of environmental factors affecting development of islet autoimmunity or T1D, and to gain insight on mechanisms. 3) Collect and bank specimens for studies of T1D pathogenesis and development of biomarkers for T1D prediction. The prospectively collected specimens on TEDDY subjects provide a unique opportunity for scientists within and outside the TEDDY consortium to test novel hypotheses by performing otherwise impossible critical studies.
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|Riikonen, Anne; Hadley, David; Uusitalo, Ulla et al. (2018) Milk feeding and first complementary foods during the first year of life in the TEDDY study. Matern Child Nutr 14:e12611|
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|Koletzko, Sibylle; Lee, Hye-Seung; Beyerlein, Andreas et al. (2018) Cesarean Section on the Risk of Celiac Disease in the Offspring: The Teddy Study. J Pediatr Gastroenterol Nutr 66:417-424|
|Stanfill, Bryan A; Nakayasu, Ernesto S; Bramer, Lisa M et al. (2018) Quality Control Analysis in Real-time (QC-ART): A Tool for Real-time Quality Control Assessment of Mass Spectrometry-based Proteomics Data. Mol Cell Proteomics 17:1824-1836|
|Lynch, Kristian F; Lee, Hye-Seung; Törn, Carina et al. (2018) Gestational respiratory infections interacting with offspring HLA and CTLA-4 modifies incident ?-cell autoantibodies. J Autoimmun 86:93-103|
|Stewart, Christopher J; Ajami, Nadim J; O'Brien, Jacqueline L et al. (2018) Temporal development of the gut microbiome in early childhood from the TEDDY study. Nature 562:583-588|
|Sharma, Ashok; Liu, Xiang; Hadley, David et al. (2018) Identification of non-HLA genes associated with development of islet autoimmunity and type 1 diabetes in the prospective TEDDY cohort. J Autoimmun 89:90-100|
|Silvis, Katherine; Aronsson, Carin A; Liu, Xiang et al. (2018) Maternal dietary supplement use and development of islet autoimmunity in the offspring: TEDDY study. Pediatr Diabetes :|
|Vatanen, Tommi; Franzosa, Eric A; Schwager, Randall et al. (2018) The human gut microbiome in early-onset type 1 diabetes from the TEDDY study. Nature 562:589-594|
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