The UNC-Chapel Hill clinical center has been a leader in the Drug-Induced Liver Injury network (DILIN) from its inception, in terms of subject recruitment, data quality, biospecimen collection, and ancillary study proposals. Dr. Paul Watkins has served as chair of the DILIN Steering Committee and has led national efforts to publicize the network and identify non-profit and corporate partners. Prospects for continued leadership in the proposed 5-year cycle have been bolstered by the inclusion of Dr. Herbert Bonkovsky, who moved last year from the University of Connecticut where he was PI of DILIN clinical site, to become vice president for research at the Carolinas Medical Center, Charlotte. Dr. Bonkovsky has maintained his leadership roles within the DILIN and has recently established the Carolinas Medical Center as a very successful DILIN recruitment site for western North Carolina. Incorporating the Carolinas Medical Center site, capitalizing on community research networks to be established by our Clinical and Translational Science Award, and expanding current referral networks will allow us to double our subject recruitment rate. We will continue to lead the network in proposing and executing ancillary studies through collaborations with researchers from UNC and at neighboring institutions, such as Duke, the Environmental Protection Agency, the National Institutes of Environmental Health Sciences, and the Hamner Institute for Health Sciences. Our experienced investigator team is dedicated to establishing an authoritative, complete and current internet website devoted to drug-induced liver injury (DILI). Finally, we will work diligently to develop and validate a simple and practical web-based instrument that will become the preferred means to establish the diagnosis of DILI.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Research Project--Cooperative Agreements (U01)
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Application #
Study Section
Special Emphasis Panel (ZDK1-GRB-8 (O1))
Program Officer
Serrano, Jose
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University of North Carolina Chapel Hill
Internal Medicine/Medicine
Schools of Medicine
Chapel Hill
United States
Zip Code
Bonkovsky, Herbert L; Barnhart, Huiman X; Foureau, David M et al. (2018) Cytokine profiles in acute liver injury-Results from the US Drug-Induced Liver Injury Network (DILIN) and the Acute Liver Failure Study Group. PLoS One 13:e0206389
Dakhoul, Lara; Ghabril, Marwan; Gu, Jiezhun et al. (2018) Heavy Consumption of Alcohol is Not Associated With Worse Outcomes in Patients With Idiosyncratic Drug-induced Liver Injury Compared to Non-Drinkers. Clin Gastroenterol Hepatol 16:722-729.e2
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Lanvers-Kaminsky, C; Zehnhoff-Dinnesen, Ag Am; Parfitt, R et al. (2017) Drug-induced ototoxicity: Mechanisms, Pharmacogenetics, and protective strategies. Clin Pharmacol Ther 101:491-500
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