This grant is submitted in response to RFA:DK-03-006 """"""""Bariatric Surgery Clinical Research Consortium"""""""". We are making application to be one of the interactive Clinical Centers in this Consortium. Our research group has had a longstanding interest in eating disorders and eating problems, and has recently been interested in research in binge eating disorder, obesity and bariatric surgery. As noted in the RFA, obesity has become an alarmingly common problem in America, and baritaric surgery procedures appear to be the treatment of choice for patients with severe obesity. However, a number of important research questions have yet to be answered. In this application we review various areas of research including the relationship between psychopathology and outcome of bariatric surgery, particularly as it relates to binge eating and binge eating disorder, the development of eating disorders as a consequence of bariatric surgery, the psychosocial outcomes of individuals undergoing bariatric surgery, psychosocial interventions for patients undergoing bariatric surgery, and peptides and feeding in bariatric surgery. Preliminary data are included detailing our experiences in working with this population including an ongoing project collecting standardized databases on patients undergoing bariatric surgery at various sites, two follow-up studies that have been completed status post-gastric bypass, and our experience with various modalities which could be helpful to the consortium. These include ecological momentary assessment paradigms, the use of structured and self-report instruments, the assessment of quality of life and studies of eating behavior and peptides in our human feeding laboratory. We propose two experiments. The first is a short-term study examining eating behavior both pre- and post-bariatric surgery using 72 hour dietary recall, ecological momentary assessment and feeding laboratory assessment over a period of 9 months. A second longer-term study would involve a 24 month prospective longitudinal design with a careful assessment of psychopathology and various behavioral variables that might impact on response to surgery, on the amount of weight loss, the amount of weight regained, and on psychosocial complications post operatively, as well as quality of life. Specific hypotheses are offered regarding both of these experiments.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project--Cooperative Agreements (U01)
Project #
1U01DK066471-01
Application #
6726533
Study Section
Special Emphasis Panel (ZDK1-GRB-4 (O1))
Program Officer
Miles, Carolyn
Project Start
2003-09-30
Project End
2008-08-31
Budget Start
2003-09-30
Budget End
2004-08-31
Support Year
1
Fiscal Year
2003
Total Cost
$278,312
Indirect Cost
Name
Neuropsychiatric Research Institute
Department
Type
DUNS #
068157924
City
Fargo
State
ND
Country
United States
Zip Code
58103
Field, Alison E; Inge, Thomas H; Belle, Steven H et al. (2018) Association of Obesity Subtypes in the Longitudinal Assessment of Bariatric Surgery Study and 3-Year Postoperative Weight Change. Obesity (Silver Spring) 26:1931-1937
O'Rourke, Robert W; Johnson, Geoffrey S; Purnell, Jonathan Q et al. (2018) Serum biomarkers of inflammation and adiposity in the LABS cohort: associations with metabolic disease and surgical outcomes. Int J Obes (Lond) :
Purnell, Jonathan Q; Johnson, Geoffrey S; Wahed, Abdus S et al. (2018) Prospective evaluation of insulin and incretin dynamics in obese adults with and without diabetes for 2 years after Roux-en-Y gastric bypass. Diabetologia 61:1142-1154
King, Wendy C; Hinerman, Amanda S; Belle, Steven H et al. (2018) Comparison of the Performance of Common Measures of Weight Regain After Bariatric Surgery for Association With Clinical Outcomes. JAMA 320:1560-1569
Friedman, Allon N; Wahed, Abdus S; Wang, Junyao et al. (2018) Effect of Bariatric Surgery on CKD Risk. J Am Soc Nephrol 29:1289-1300
Menke, Marie N; King, Wendy C; White, Gretchen E et al. (2017) Contraception and Conception After Bariatric Surgery. Obstet Gynecol 130:979-987
King, Wendy C; Chen, Jia-Yuh; Courcoulas, Anita P et al. (2017) Alcohol and other substance use after bariatric surgery: prospective evidence from a U.S. multicenter cohort study. Surg Obes Relat Dis 13:1392-1402
King, Wendy C; Chen, Jia-Yuh; Belle, Steven H et al. (2017) Use of prescribed opioids before and after bariatric surgery: prospective evidence from a U.S. multicenter cohort study. Surg Obes Relat Dis 13:1337-1346
Kalarchian, Melissa A; King, Wendy C; Devlin, Michael J et al. (2016) Psychiatric Disorders and Weight Change in a Prospective Study of Bariatric Surgery Patients: A 3-Year Follow-Up. Psychosom Med 78:373-81
Alfonso-Cristancho, Rafael; King, Wendy C; Mitchell, James E et al. (2016) Longitudinal Evaluation of Work Status and Productivity After Bariatric Surgery. JAMA 316:1595-1597

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