Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project--Cooperative Agreements (U01)
Project #
3U01HD031313-08S1
Application #
6079325
Study Section
Special Emphasis Panel (ZHD1-MCHG-B (HN))
Program Officer
Grave, Gilman D
Project Start
1994-01-01
Project End
2002-12-31
Budget Start
2000-03-01
Budget End
2000-12-31
Support Year
8
Fiscal Year
2000
Total Cost
$101,646
Indirect Cost
Name
Children's Mercy Hosp (Kansas City, MO)
Department
Type
DUNS #
City
Kansas City
State
MO
Country
United States
Zip Code
64108
Jones, Bridgette L; Kearns, Gregory; Neville, Kathleen A et al. (2013) Variability of histamine pharmacodynamic response in children with allergic rhinitis. J Clin Pharmacol 53:731-7
Kearns, Gregory L; Leeder, J Steven; Gaedigk, Andrea (2010) Impact of the CYP2C19*17 allele on the pharmacokinetics of omeprazole and pantoprazole in children: evidence for a differential effect. Drug Metab Dispos 38:894-7
Leeder, J Steven; Kearns, Gregory L; Spielberg, Stephen P et al. (2010) Understanding the relative roles of pharmacogenetics and ontogeny in pediatric drug development and regulatory science. J Clin Pharmacol 50:1377-87
Blake, Michael J; Abdel-Rahman, Susan M; Pearce, Robin E et al. (2006) Effect of diet on the development of drug metabolism by cytochrome P-450 enzymes in healthy infants. Pediatr Res 60:717-23
Pearce, Robin E; Leeder, J Steven; Kearns, Gregory L (2006) Biotransformation of fluticasone: in vitro characterization. Drug Metab Dispos 34:1035-40
Capparelli, Edmund V; Reed, Michael D; Bradley, John S et al. (2005) Pharmacokinetics of gatifloxacin in infants and children. Antimicrob Agents Chemother 49:1106-12
Blake, Michael J; Castro, Lisa; Leeder, J Steven et al. (2005) Ontogeny of drug metabolizing enzymes in the neonate. Semin Fetal Neonatal Med 10:123-38
James, Laura P; Simpson, Pippa M; Farrar, Henry C et al. (2005) Cytokines and toxicity in acetaminophen overdose. J Clin Pharmacol 45:1165-71
Kennedy, Mary Jayne; Jackson, Mary Anne; Kearns, Gregory L (2004) Delayed diagnosis of penicillin-resistant Streptococcus mitis endocarditis following single-dose amoxicillin prophylaxis in a child. Clin Pediatr (Phila) 43:773-6
Kennedy, Mary Jayne; Abdel-Rahman, Susan M; Kashuba, Angela D M et al. (2004) Comparison of various urine collection intervals for caffeine and dextromethorphan phenotyping in children. J Clin Pharmacol 44:708-14

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