The Southern California WIHS Consortium (SCWC) has been established to participate in the national WIHS/HERS Project, in order to define (1) the spectrum and course of HIV infection in women; (2) the pattern and rate of decline of CD4 cells in these women; (3) those factors which may delay or accelerate immune dysfunction; and (4) those factors which influence the quantity and quality of survival. Further aims include the determination of (1) the rate of incident HIV seroconversion and factors associated with infection in a cohort of HIV-negative women at risk; and (2) the feasibility of vaccine trials in this group. To these ends, our SCWC Consortium was designed to accrue subjects who will represent the rich ethnic, cultural, and socioeconomic diversity which characterizes Southern California. A total of 600 HIV-positive patients, and 150 HIV-negative women at risk will be accrued from seven sites: (1) University of Southern California School of Medicine and the Los Angeles County-USC Medical Center; (2) The Charles Drew University of Medicine, and the Martin Luther King Medical Center; (3) The AIDS Healthcare Foundation, and Southwest Community Based AIDS Treatment Group (AmFAR CBCT Network); (4) SEARCH Alliance (AmFAR CBCT Network); (5) the Santa Barbara County Department of Health Services; (6) T.H.E. Clinic for Women, a private non-profit community clinic providing comprehensive health care to minority women; and (7) Prototypes/W.A.R.N. + Women's Center, a center for the care and counseling of women with drug use history. Through this Consortium, of the 600 HIV-positives, 42% will be Latina; 31% African-American; 25% Caucasian; and 2% other. Sources of HIV infection will include approximately 60% by heterosexual contact; 18% by injection drug use; 9% by transfusion; and 13% by unknown factors. Our identified pool of 150 HIV negative women at risk provides an almost identical distribution of ethnic and risk-behavior groups. On-going participation from a Community Advisory Board (CAB), along with strong, existing linkages with multiple AIDS service agencies will allow accrual of the planned cohort. Bilingual personnel, sensitive to cultural issues will be hired; 70% of the PI/Co-PIs on this grant are women or minorities SCWC personnel from all sites will undergo specific Training Sessions. By provision of specific comprehensive support services, including transportation; child care; food; social services and other incentives; and a patient tracking system, we will retain approximately 80% of the accrued cohort. HERS study procedures will be refined and used in accordance with central WIHS guidelines to follow all subjects over time.

National Institute of Health (NIH)
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Research Project--Cooperative Agreements (U01)
Project #
Application #
Study Section
Special Emphasis Panel (ZAI1-PRJ-A (O2))
Program Officer
Nugent, Robert
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Southern California
Internal Medicine/Medicine
Schools of Medicine
Los Angeles
United States
Zip Code
Grover, Surbhi; Desir, Fidel; Jing, Yuezhou et al. (2018) Reduced Cancer Survival Among Adults With HIV and AIDS-Defining Illnesses Despite No Difference in Cancer Stage at Diagnosis. J Acquir Immune Defic Syndr 79:421-429
Radtke, Kendra K; Bacchetti, Peter; Anastos, Kathryn et al. (2018) Use of Nonantiretroviral Medications That May Impact Neurocognition: Patterns and Predictors in a Large, Long-Term HIV Cohort Study. J Acquir Immune Defic Syndr 78:202-208
Yang, Jingyan; Sharma, Anjali; Shi, Qiuhu et al. (2018) Improved fracture prediction using different fracture risk assessment tool adjustments in HIV-infected women. AIDS 32:1699-1706
Tang, Yuyang; George, Alvin M; Petrechko, Oksana et al. (2018) Pseudotyping of HIV-1 with Human T-Lymphotropic Virus 1 (HTLV-1) Envelope Glycoprotein during HIV-1-HTLV-1 Coinfection Facilitates Direct HIV-1 Infection of Female Genital Epithelial Cells: Implications for Sexual Transmission of HIV-1. mSphere 3:
Huck, Daniel M; Hanna, David B; Rubin, Leah H et al. (2018) Carotid Artery Stiffness and Cognitive Decline Among Women With or at Risk for HIV Infection. J Acquir Immune Defic Syndr 78:338-347
Elion, Richard A; Althoff, Keri N; Zhang, Jinbing et al. (2018) Recent Abacavir Use Increases Risk of Type 1 and Type 2 Myocardial Infarctions Among Adults With HIV. J Acquir Immune Defic Syndr 78:62-72
Sharma, Anjali; Hoover, Donald R; Shi, Qiuhu et al. (2018) Longitudinal study of falls among HIV-infected and uninfected women: the role of cognition. Antivir Ther 23:179-190
Sharma, Anjali; Hoover, Donald R; Shi, Qiuhu et al. (2018) Frequent Occurrence of Pain and Prescription Opioid Use for Treatment of Pain Among Women with and at Risk for HIV Infection. AIDS Behav 22:2008-2017
Palar, Kartika; Frongillo, Edward A; Escobar, Jessica et al. (2018) Food Insecurity, Internalized Stigma, and Depressive Symptoms Among Women Living with HIV in the United States. AIDS Behav 22:3869-3878
Maki, Pauline M; Rubin, Leah H; Springer, Gayle et al. (2018) Differences in Cognitive Function Between Women and Men With HIV. J Acquir Immune Defic Syndr 79:101-107

Showing the most recent 10 out of 531 publications