The Collaborative Pediatric Critical Care Research Network was established in 2005 to support multicenter randomized controlled trials and observational studies in critically ill children. In the first 46 months (May 2005 March 2009), CPCCRN has created a network registry, developed a novel functional status outcome scale, conducted several studies of pathologic bereavement, implemented a RCT to prevent nosocomial sepsis (requiring an IND from the FDA), and validated a novel method for measuring free serum Cortisol. CPCCRN has also collaborated with non-CPCCRN institutions to measure the burden of critical pertussis in the United States, and actively participated in developing an NHLBl-funded pediatric RCT of hypothermia after cardiac arrest. Going forward, the network has fully developed protocols in its pipeline to study opioid tolerance (MOTIF) and to identify usable outcomes for sepsis trials (COMPASS). CPCCRN investigators are developing computerized decision support tools for studies of pediatric mechanical ventilation. In the initial 46 months, CPCCRN activities have contributed to 11 peer-reviewed publications.The University of Utah is the Data Coordinating Center (DCC) for CPCCRN, and proposes to continue in this role during the next five years. The DCC faculty bring recognized clinical, biostatistical, and informatics expertise to the CPCCRN. This proposal has three specific aims.
Specific Aim 1. Provide clinical and biostatistical leadership and expertise, assistance in study and protocol design, study implementation and coordination, interim and final study analysis, tracking and delivery methods for study drugs and biological specimens, data collection and management, site monitoring, and active support for dissemination of study results.
Specific Aim 2. Provide logistical support for CPCCRN (including financial management of protocol funds), using advanced communication and informatics tools for development and tracking of critical documents, protocols. Manuals of Operation, publications, reports, and provision of accounting information to NICHD.
Specific Aim 3. Develop detailed computerized protocols for management of vasoactive drips, to support future potential CPCCRN studies of pediatric septic shock (DCC Concept Proposal).
The CPCCRN carries out clinical trials and studies to improve the science of pediatric intensive care and to reduce the mortality and improve the long term outcome for infants and children who suffer from critical illness or injury.
|Basu, Sonali; Holubkov, Richard; Dean, J Michael et al. (2018) PICU Autopsies: Rates, Patient Characteristics, and the Role of the Medical Examiner. Pediatr Crit Care Med 19:1137-1145|
|Cornell, Timothy T; Selewski, David T; Alten, Jeffrey A et al. (2018) Acute kidney injury after out of hospital pediatric cardiac arrest. Resuscitation 131:63-68|
|Zinter, Matt S; Holubkov, Richard; Steurer, Martina A et al. (2018) Pediatric Hematopoietic Cell Transplant Patients Who Survive Critical Illness Frequently Have Significant but Recoverable Decline in Functional Status. Biol Blood Marrow Transplant 24:330-336|
|Berg, Robert A; Reeder, Ron W; Meert, Kathleen L et al. (2018) End-tidal carbon dioxide during pediatric in-hospital cardiopulmonary resuscitation. Resuscitation 133:173-179|
|Cashen, Katherine; Reeder, Ron; Dalton, Heidi J et al. (2018) Hyperoxia and Hypocapnia During Pediatric Extracorporeal Membrane Oxygenation: Associations With Complications, Mortality, and Functional Status Among Survivors. Pediatr Crit Care Med 19:245-253|
|Pollack, Murray M; Holubkov, Richard; Reeder, Ron et al. (2018) PICU Length of Stay: Factors Associated With Bed Utilization and Development of a Benchmarking Model. Pediatr Crit Care Med 19:196-203|
|Pollack, Murray M; Holubkov, Richard; Berg, Robert A et al. (2018) Predicting cardiac arrests in pediatric intensive care units. Resuscitation 133:25-32|
|Cashen, Katherine; Reeder, Ron; Dalton, Heidi J et al. (2018) Acquired infection during neonatal and pediatric extracorporeal membrane oxygenation. Perfusion 33:472-482|
|Berg, Robert A; Sutton, Robert M; Reeder, Ron W et al. (2018) Association Between Diastolic Blood Pressure During Pediatric In-Hospital Cardiopulmonary Resuscitation and Survival. Circulation 137:1784-1795|
|Meert, Kathleen; Telford, Russell; Holubkov, Richard et al. (2018) Paediatric in-hospital cardiac arrest: Factors associated with survival and neurobehavioural outcome one year later. Resuscitation 124:96-105|
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