The last decade has seen substantial discoveries of genetic determinants of disease risk and drug response, along with staggering technological advances in genotyping, leading to the expectation that an individual's personal genome will eventually be part of their medical record, to guide care decisions across their lifespan. However, despite these advances, there has been minimal translation of this information to clinical practice. We recently launched a genomic medicine program at the University of Florida and Shands Hospital (the UF&Shands Personalized Medicine Program (PMP)), which seeks to advance the clinical utilization of genomic information to optimize patient care. Our program is built on three guiding principles. 1) There is a regulatory body that evaluates the literature to determine when the level of evidence is sufficient to warrant clinical implementation, and when this occurs, develops specific recommendations regarding use of the genetic information;2) the most efficient manner of implementation is through a broad, pre-emptive genotyping chip, such that information can be generated once, and used across the patient's lifespan;3) the program must be supported through specific informatics clinical decision support within the electronic medical record so the clinician receives clear recommendations to guide use of the genetic information. The UF&Shands PMP is currently focused on a pharmacogenetic example, but we have built the program for wider translation of pharmacogenetics and genetics findings into clinical practice. During the past year we established the institutional infrastructure necessary t support the PMP, and are now poised to expand the program, and use our experiences to implement similar programs in large, private health systems, and community healthcare settings.
Our specific aims are to:
Specific Aim 1. Expand and assess the impact of the clinical implementation of pharmacogenetic information to guide treatment decisions at UF&Shands through expansion to broader patient populations and to additional drug-genotype combinations on which clinical decisions are based.
Specific Aim 2. Implement and assess the PMP at diverse institutions outside the UF&Shands Health System, including a) the Orlando Health Heart Institute, a private cardiology group practice that is part Orlando Health, a large, private health system, and, b) a small community hospital through the Florida State University (FSU) College of Medicine practice network.
Specific Aim 3. To insure appropriate levels of knowledge about genomic medicine, develop and implement innovative genomic medicine educational programs for: 3a. physicians and other health-care providers;3b. health professions students;and 3c. patients. Implementation of genomic medicine into patient care has the potential to substantially improve outcomes of patients. Achieving these goals requires development and implementation of successful approaches for incorporation of genomic information into existing, complex healthcare systems, and documenting benefit of genomic medicine, each of which are addressed by our proposed aims.
Use of genetic information to guide the treatment of patients has the potential to significantly improve patient outcomes, but there are not well-established models in place for how to do this in our current health systems. We propose to expand the genomic medicine program at the University of Florida and extend the program to other, private health systems in Florida, in order to document the methods for using genetic information in clinical care, along with documenting the benefits of using genetic information. We will also establish a variety of educational programs on genomic medicine, targeted at health care providers, health professions students, and patients.
| Moon, Jae Youn; Franchi, Francesco; Rollini, Fabiana et al. (2018) Role of genetic testing in patients undergoing percutaneous coronary intervention. Expert Rev Clin Pharmacol 11:151-164 |
| Zebrowski, Alexis M; Ellis, Darcy E; Barg, Frances K et al. (2018) Qualitative study of system-level factors related to genomic implementation. Genet Med : |
| El Rouby, Nihal; Lima, John J; Johnson, Julie A (2018) Proton pump inhibitors: from CYP2C19 pharmacogenetics to precision medicine. Expert Opin Drug Metab Toxicol 14:447-460 |
| Empey, Philip E; Stevenson, James M; Tuteja, Sony et al. (2018) Multisite Investigation of Strategies for the Implementation of CYP2C19 Genotype-Guided Antiplatelet Therapy. Clin Pharmacol Ther 104:664-674 |
| Weitzel, Kristin W; Smith, D Max; Elsey, Amanda R et al. (2018) Implementation of Standardized Clinical Processes for TPMT Testing in a Diverse Multidisciplinary Population: Challenges and Lessons Learned. Clin Transl Sci 11:175-181 |
| Cavallari, Larisa H; Lee, Craig R; Beitelshees, Amber L et al. (2018) Multisite Investigation of Outcomes With Implementation of CYP2C19 Genotype-Guided Antiplatelet Therapy After Percutaneous Coronary Intervention. JACC Cardiovasc Interv 11:181-191 |
| Smith, D Max; Weitzel, Kristin W; Cavallari, Larisa H et al. (2018) Clinical application of pharmacogenetics in pain management. Per Med 15:117-126 |
| Rivas Rios, Jose R; Franchi, Francesco; Rollini, Fabiana et al. (2018) Diabetes and antiplatelet therapy: from bench to bedside. Cardiovasc Diagn Ther 8:594-609 |
| Mosley, Scott A; Hicks, J Kevin; Portman, Diane G et al. (2018) Design and rational for the precision medicine guided treatment for cancer pain pragmatic clinical trial. Contemp Clin Trials 68:7-13 |
| Weitzel, Kristin W; Cavallari, Larisa H; Lesko, Lawrence J (2017) Preemptive Panel-Based Pharmacogenetic Testing: The Time is Now. Pharm Res 34:1551-1555 |
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