Abstract

Sarcoidosis is a systemic granulomatous disease of unknown etiology that likely involves exposure to some environmental agent in a genetically susceptible host. We propose to identify sarcoidosis susceptibility genes and determine how thee genes and environmental risk factors interact to cayuse sarcoidosis. This will be accomplished by organizing a multicenter consortium to recruit an adequate sample of sarcoidosis families for analysis We plan to use affected sibling pair linkage analysis to scan the genome for linked chromosomal regions, transmission disequilibrium testing to evaluate candidate genes in those regions with evidence for linkage and an environmental questionnaire to collect data for possible interactions of susceptibility genes with exogenous risk factors.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01HL060263-04
Application #
6631287
Study Section
Project Start
2002-05-01
Project End
2003-04-30
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
4
Fiscal Year
2002
Total Cost
$238,838
Indirect Cost

  Institution

Name
Henry Ford Health System
Department
Type
DUNS #
073134603
City
Detroit
State
MI
Country
United States
Zip Code
48202

  Publications

Lareau, C A; DeWeese, C F; Adrianto, I et al. (2017) Polygenic risk assessment reveals pleiotropy between sarcoidosis and inflammatory disorders in the context of genetic ancestry. Genes Immun 18:88-94
Levin, Albert M; Adrianto, Indra; Datta, Indrani et al. (2015) Association of HLA-DRB1 with Sarcoidosis Susceptibility and Progression in African Americans. Am J Respir Cell Mol Biol 53:206-16
Li, Jia; Yang, James; Levin, Albert M et al. (2014) Efficient generalized least squares method for mixed population and family-based samples in genome-wide association studies. Genet Epidemiol 38:430-8
Levin, Albert M; Iannuzzi, Michael C; Montgomery, Courtney G et al. (2014) Admixture fine-mapping in African Americans implicates XAF1 as a possible sarcoidosis risk gene. PLoS One 9:e92646
Levin, Albert M; Adrianto, Indra; Datta, Indrani et al. (2014) Performance of HLA allele prediction methods in African Americans for class II genes HLA-DRB1, -DQB1, and -DPB1. BMC Genet 15:72
Adrianto, Indra; Lin, Chee Paul; Hale, Jessica J et al. (2012) Genome-wide association study of African and European Americans implicates multiple shared and ethnic specific loci in sarcoidosis susceptibility. PLoS One 7:e43907
Iannuzzi, Michael C; Rybicki, Benjamin A (2007) Genetics of sarcoidosis: candidate genes and genome scans. Proc Am Thorac Soc 4:108-16
Iannuzzi, Michael C; Rybicki, Benjamin A; Teirstein, Alvin S (2007) Sarcoidosis. N Engl J Med 357:2153-65
Rybicki, B A; Sinha, R; Iyengar, S et al. (2007) Genetic linkage analysis of sarcoidosis phenotypes: the sarcoidosis genetic analysis (SAGA) study. Genes Immun 8:379-86
Thompson, Cheryl L; Rybicki, Benjamin A; Iannuzzi, Michael C et al. (2006) Reduction of sample heterogeneity through use of population substructure: an example from a population of African American families with sarcoidosis. Am J Hum Genet 79:606-13

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