Abstract

The NIMH Collaborative Program on Psychobiology of Depression addresses two major substantive areas: 1) Nosology: To evaluate the comparative validity of alternative systems for clinical classification. 2) Genetics: To evaluate recent hypotheses that genetic factors are involved in the evolution of certain types of depressive disorders. In addition, this study also addresses a variety of other areas, including personality factors, life events, social supports, sociodemographic variables, and phenomenology. In addition to the comprehensive genetic study, family history variables are investigated in each proband. Finally, a large-scale follow-up investigation will also be completed on each subject.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01MH025416-13
Application #
3553777
Study Section
(SRC)
Project Start
1977-07-01
Project End
1987-06-30
Budget Start
1986-07-01
Budget End
1987-06-30
Support Year
13
Fiscal Year
1986
Total Cost
Indirect Cost

  Institution

Name
University of Iowa
Department
Type
Schools of Medicine
DUNS #
041294109
City
Iowa City
State
IA
Country
United States
Zip Code
52242

  Publications

Coryell, William; Fiedorowicz, Jess; Leon, Andrew C et al. (2013) Age of onset and the prospectively observed course of illness in bipolar disorder. J Affect Disord 146:34-8
Fiedorowicz, Jess G; Palagummi, Narasimha M; Behrendtsen, Ole et al. (2010) Cholesterol and affective morbidity. Psychiatry Res 175:78-81
Coryell, William; Solomon, David; Turvey, Carolyn et al. (2003) The long-term course of rapid-cycling bipolar disorder. Arch Gen Psychiatry 60:914-20
Coryell, W; Schlesser, M (2001) The dexamethasone suppression test and suicide prediction. Am J Psychiatry 158:748-53
Coryell, W; Akiskal, H; Leon, A C et al. (2000) Family history and symptom levels during treatment for bipolar I affective disorder. Biol Psychiatry 47:1034-42
Andreasen, N C; Glick, I D (1988) Bipolar affective disorder and creativity: implications and clinical management. Compr Psychiatry 29:207-17
Andreasen, N C; Rice, J; Endicott, J et al. (1986) The family history approach to diagnosis. How useful is it? Arch Gen Psychiatry 43:421-9
Andreasen, N C; Scheftner, W; Reich, T et al. (1986) The validation of the concept of endogenous depression. A family study approach. Arch Gen Psychiatry 43:246-51
Coryell, W; Endicott, J; Keller, M et al. (1985) Phenomenology and family history in DSM-III psychotic depression. J Affect Disord 9:13-8
Coryell, W; Endicott, J; Andreasen, N et al. (1985) Bipolar I, bipolar II, and nonbipolar major depression among the relatives of affectively ill probands. Am J Psychiatry 142:817-21