The Clinical Studies of the NIMH Collaborative Program on the Psychobiology of Depression involves an interrelated and coordinated group of investigations conducted on two samples drawn from five centers -- mood disordered probands and their relatives. This application seeks to continue the follow-up of the samples and to implement several new, but related aims: 1) Investigation of the long-term course of illness in probands, relatives, spouses, and controls. 2) Determination of predictors of onset and recurrence in the same samples. 3) Investigation of suicidal behavior, mortality, and medical morbidity. 4) Investigation of personality disorders in the samples, including validity, joint familial transmission with mood disorders, and influence on clinical course of mood disorders. 5) A genetic linkage study of unipolar families. 6) Investigation of stability of diagnosis on familial modes of transmission. 7) Further investigation of secular trends in the occurrence of mood disorders.
These aims have important public health, clinical, and research implications.
Coryell, William; Fiedorowicz, Jess; Leon, Andrew C et al. (2013) Age of onset and the prospectively observed course of illness in bipolar disorder. J Affect Disord 146:34-8 |
Fiedorowicz, Jess G; Palagummi, Narasimha M; Behrendtsen, Ole et al. (2010) Cholesterol and affective morbidity. Psychiatry Res 175:78-81 |
Coryell, William; Solomon, David; Turvey, Carolyn et al. (2003) The long-term course of rapid-cycling bipolar disorder. Arch Gen Psychiatry 60:914-20 |
Coryell, W; Schlesser, M (2001) The dexamethasone suppression test and suicide prediction. Am J Psychiatry 158:748-53 |
Coryell, W; Akiskal, H; Leon, A C et al. (2000) Family history and symptom levels during treatment for bipolar I affective disorder. Biol Psychiatry 47:1034-42 |
Andreasen, N C; Glick, I D (1988) Bipolar affective disorder and creativity: implications and clinical management. Compr Psychiatry 29:207-17 |
Andreasen, N C; Rice, J; Endicott, J et al. (1986) The family history approach to diagnosis. How useful is it? Arch Gen Psychiatry 43:421-9 |
Andreasen, N C; Scheftner, W; Reich, T et al. (1986) The validation of the concept of endogenous depression. A family study approach. Arch Gen Psychiatry 43:246-51 |
Coryell, W; Endicott, J; Keller, M et al. (1985) Phenomenology and family history in DSM-III psychotic depression. J Affect Disord 9:13-8 |
Coryell, W; Endicott, J; Andreasen, N et al. (1985) Bipolar I, bipolar II, and nonbipolar major depression among the relatives of affectively ill probands. Am J Psychiatry 142:817-21 |