This is a proposal for the NIMH Collaborative Program on the Psychobiology of Depression (""""""""the Collaborative Depression Study""""""""). The purpose of this application for the Cooperative Agreement is to continue the collaborative effort of a group senior investigators and the NIMH that has functioned smoothly, efficiently, and productively for over a decade. The Cooperative Agreement application requests support for the maintenance of the infrastructure of communication and administration of the Collaborative Depression Study. This infrastructure will ensure continued scientific integrity of the Collaborative Depression Study, protect its sample and data base, and provide ongoing policy and organization for analysis of data and publication of results. The Cooperative Agreement will also support the Publication Committee which has authority over presentation and publication of all data emanating from more than one center. This committee reviews proposed analyses, abstracts, manuscripts, etc. to assure adequate sharing of data and quality control. Finally, the Cooperative Agreement will support Cluster Committees, which are organized around functional tasks in substantive areas, and serve to plan and execute important activities of the Collaborative Depression Study. These committees are responsible for making recommendations regarding plans and explication of issues, assessment of alternatives and the conduct of data analyses in each area.
| Neuman, R J; Geller, B; Rice, J P et al. (1997) Increased prevalence and earlier onset of mood disorders among relatives of prepubertal versus adult probands. J Am Acad Child Adolesc Psychiatry 36:466-73 |
| Neuman, R J; Kwon, J M; Jilek-Aall, L et al. (1995) Genetic analysis of kifafa, a complex familial seizure disorder. Am J Hum Genet 57:902-10 |
| Moldin, S O; Rice, J P; Erlenmeyer-Kimling, L et al. (1994) Latent structure of DSM-III-R Axis II psychopathology in a normal sample. J Abnorm Psychol 103:259-66 |
| Rice, J P; Todorov, A A (1994) Stability of diagnosis: application to phenotype definition. Schizophr Bull 20:185-90 |
| Neuman, R J; Rice, J P (1994) A bit about haplotypes: using binary digits to code tightly linked loci. Hum Hered 44:241-7 |
| Moldin, S O; Scheftner, W A; Rice, J P et al. (1993) Association between major depressive disorder and physical illness. Psychol Med 23:755-61 |
| Neuman, R J; Rice, J P; Hampe, C L et al. (1993) Linkage analysis of a complex disease: application to familial Alzheimer's disease. Genet Epidemiol 10:419-24 |
| Rice, J P (1993) Phenotype definition for genetic studies. Eur Arch Psychiatry Clin Neurosci 243:158-63 |
| Neuman, R; Van Eerdewegh, P; Moldin, S et al. (1992) Genetic analysis of cutaneous melanoma and dysplastic nevi under varying phenotypic definitions. Cytogenet Cell Genet 59:214-6 |
| Neuman, R J; Rice, J P (1992) Two-locus models of disease. Genet Epidemiol 9:347-65 |
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