The collaborative team for the Collaborative Depression Study (CDS) propose to continue data collection for five additional years of the original cohort of the Psychobiology of Depression Study (now called the Collaborative Depression Study). The general aims of this proposal are to provide data to the field that will help: 1) describe the long term patterns of psychopathology of affective disorders using the recovery and recurrence of syndromes as the outcome; 2) study the influence of somatic treatment as a mediating variable affecting outcome in naturalistic studies and to describe the type and dose of somatic and psychosocial treatment received by patients suffering from major affective illness; 3) further contrast diagnostic groups in light of much longer observation periods; 4) extend the domains of outcomes studied to include psychosocial functioning, physical health, medical comorbidity and personality functioning; 5) study suicide, mortality, and medical morbidity as long- term outcomes of affective disorders. In order to accomplish these aims this application requests funds to: 1) extend the prospective annual follow-up of the CDS proband sample to at least 16 years on all subjects; 2) provide public access tapes of previously collected proband, relative, spouse and control data from the CDS; 3) provide public access tapes for the newly-collected proband data.
| Neuman, R J; Geller, B; Rice, J P et al. (1997) Increased prevalence and earlier onset of mood disorders among relatives of prepubertal versus adult probands. J Am Acad Child Adolesc Psychiatry 36:466-73 |
| Neuman, R J; Kwon, J M; Jilek-Aall, L et al. (1995) Genetic analysis of kifafa, a complex familial seizure disorder. Am J Hum Genet 57:902-10 |
| Moldin, S O; Rice, J P; Erlenmeyer-Kimling, L et al. (1994) Latent structure of DSM-III-R Axis II psychopathology in a normal sample. J Abnorm Psychol 103:259-66 |
| Rice, J P; Todorov, A A (1994) Stability of diagnosis: application to phenotype definition. Schizophr Bull 20:185-90 |
| Neuman, R J; Rice, J P (1994) A bit about haplotypes: using binary digits to code tightly linked loci. Hum Hered 44:241-7 |
| Moldin, S O; Scheftner, W A; Rice, J P et al. (1993) Association between major depressive disorder and physical illness. Psychol Med 23:755-61 |
| Neuman, R J; Rice, J P; Hampe, C L et al. (1993) Linkage analysis of a complex disease: application to familial Alzheimer's disease. Genet Epidemiol 10:419-24 |
| Rice, J P (1993) Phenotype definition for genetic studies. Eur Arch Psychiatry Clin Neurosci 243:158-63 |
| Neuman, R; Van Eerdewegh, P; Moldin, S et al. (1992) Genetic analysis of cutaneous melanoma and dysplastic nevi under varying phenotypic definitions. Cytogenet Cell Genet 59:214-6 |
| Neuman, R J; Rice, J P (1992) Two-locus models of disease. Genet Epidemiol 9:347-65 |
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