The Columbus Children's Hospital (CCH) in Columbus, Ohio proposes with this Grant to conduct multi-disciplinary cancer research in childhood malignancy within the Children's Cancer Study Group (CCSG). CCH will provide leadership within CCSG as Chairmen/Members of the CCSG working committees and provide for leadership and patient entry into Phase I, II, and III studies within CCSG. CCH will seek to provide laboratory support for brain tumor studies requiring drug sensitivity testing. The investigators at CCH will represent the interests of CCSG on the Intergroup Rhabdomyosarcoma Study providing advice on protocol development, treatment, slide review, chart review, and clinical research. Investigators at CCH agree to participate in investigational studies of CCSG in compliance with FDA and NCI guidelines. Appropriate approval by the Columbus Children's Hospital Human Subjects Research Committee and CCH's Investigational Review Board will be obtained. Data will be maintained on an appropriate flow sheet system and in compliance with the protocol guidelines. Future plans will include the continued development of major laboratory research in Hematology/Oncology, which will interface and support the scientific development of protocols in CCSG. The implementation of a bone marrow transplant program at the Ohio State University Comprehensive Cancer Center in collaboration with CCH will be supportive of CCSG investigations. CCH will continue to be a keystone institution in the accrual of patients on study and in the development of innovative cancer treatment protocols for childhood malignancy.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
5U10CA003750-29
Application #
3555770
Study Section
Cancer Clinical Investigation Review Committee (CCI)
Project Start
1976-12-01
Project End
1988-11-30
Budget Start
1985-12-01
Budget End
1986-11-30
Support Year
29
Fiscal Year
1986
Total Cost
Indirect Cost
Name
Nationwide Children's Hospital
Department
Type
DUNS #
City
Columbus
State
OH
Country
United States
Zip Code
43205
Neudorf, Steven; Sanders, Jean; Kobrinsky, Nathan et al. (2004) Allogeneic bone marrow transplantation for children with acute myelocytic leukemia in first remission demonstrates a role for graft versus leukemia in the maintenance of disease-free survival. Blood 103:3655-61
Shamberger, Robert C; LaQuaglia, Michael P; Gebhardt, Mark C et al. (2003) Ewing sarcoma/primitive neuroectodermal tumor of the chest wall: impact of initial versus delayed resection on tumor margins, survival, and use of radiation therapy. Ann Surg 238:563-7; discussion 567-8
Bayoumy, Mohamed; Wynn, Tung; Jamil, Altaf et al. (2003) Prenatal presentation supports the in utero development of congenital leukemia: a case report. J Pediatr Hematol Oncol 25:148-52
Casillas, Jacqueline N; Woods, William G; Hunger, Stephen P et al. (2003) Prognostic implications of t(10;11) translocations in childhood acute myelogenous leukemia: a report from the Children's Cancer Group. J Pediatr Hematol Oncol 25:594-600
Davies, Stella M; Bhatia, Smita; Ross, Julie A et al. (2002) Glutathione S-transferase genotypes, genetic susceptibility, and outcome of therapy in childhood acute lymphoblastic leukemia. Blood 100:67-71
Wells, Robert J; Reid, Joel M; Ames, Matthew M et al. (2002) Phase I trial of cisplatin and topotecan in children with recurrent solid tumors: Children's Cancer Group Study 0942. J Pediatr Hematol Oncol 24:89-93
Lange, Beverly J; Bostrom, Bruce C; Cherlow, Joel M et al. (2002) Double-delayed intensification improves event-free survival for children with intermediate-risk acute lymphoblastic leukemia: a report from the Children's Cancer Group. Blood 99:825-33
Ou, Shu Xiao; Han, Dehui; Severson, Richard K et al. (2002) Birth characteristics, maternal reproductive history, hormone use during pregnancy, and risk of childhood acute lymphocytic leukemia by immunophenotype (United States). Cancer Causes Control 13:15-25
Cairo, M S; Krailo, M D; Morse, M et al. (2002) Long-term follow-up of short intensive multiagent chemotherapy without high-dose methotrexate ('Orange') in children with advanced non-lymphoblastic non-Hodgkin's lymphoma: a children's cancer group report. Leukemia 16:594-600
Wells, R J; Arthur, D C; Srivastava, A et al. (2002) Prognostic variables in newly diagnosed children and adolescents with acute myeloid leukemia: Children's Cancer Group Study 213. Leukemia 16:601-7

Showing the most recent 10 out of 18 publications