The Children's Cancer Center at St. Louis Children's Hospital, Washington University School of Medicine, is one of the 40 institutions and 24 affiliate institutions of the Pediatric Oncology Group who have pooled their patient resources and scientific expertise to study the natural history of childhood cancer, develop and compare effective therapeutic regimens and investigate the toxicity and effectiveness of new anticancer agents in the treatment of children with cancer. The investigators at Washington University include pediatric oncologists, radiologists, radiation therapists, neurologists, surgeons, and pathologists. All children with malignant disease are placed on cooperative group protocols if they are eligible, after informed consent is obtained. Data that is accessioned at the time the patient is placed on study protocol, during the study, and when off therapy is submitted to the Group statistical office for data analysis, interpretation and presentation. The investigators at Washington University serve in multiple administrative and research capacities for the group. The diagnostic studies, pathological findings, surgical procedure and therapeutic plan for all new patients and patients who relapse are discussed at the weekly Tumor Board Conference. Access to intensive multimodal therapy and experiment compounds is facilitated by the close contact of the center with the nearby Pediatric Oncology Group Operations Office, of which the Principal Investigator is Group Chairman. The acting principal investigator directs the effort whereby Washington University investigators review spinal fluid slides of all pediatric oncology patients to confirm the diagnosis of central nervous system leukemia, and the laboratories of two other investigators serve as Pediatric Oncology Group reference laboratories for the study of neuroblastoma tumors for N-myc and N-ras oncogene inactivation, and for the establishment of lymphoblastoid cell lines from patients so studied.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
5U10CA005587-28
Application #
3555854
Study Section
Cancer Clinical Investigation Review Committee (CCI)
Project Start
1978-01-01
Project End
1990-12-31
Budget Start
1988-01-01
Budget End
1988-12-31
Support Year
28
Fiscal Year
1988
Total Cost
Indirect Cost
Name
Washington University
Department
Type
Schools of Medicine
DUNS #
062761671
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
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Saylors 3rd, R L; Stine, K C; Sullivan, J et al. (2001) Cyclophosphamide plus topotecan in children with recurrent or refractory solid tumors: a Pediatric Oncology Group phase II study. J Clin Oncol 19:3463-9
Mahoney Jr, D H; Cohen, M E; Friedman, H S et al. (2000) Carboplatin is effective therapy for young children with progressive optic pathway tumors: a Pediatric Oncology Group phase II study. Neuro Oncol 2:213-20
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