Abstract

This is a proposal for the continued participation of Children's Memorial Hospital (CMH) and its affiliates in the program of cooperative in the program of cooperative clinical trials of the Pediatric Oncology Group (POG). This program provides the mechanism for accrual of eligible patients to an array of therapeutic and ancillary protocols aimed at improving the outcome for children with cancer through multi-disciplinary programs in the areas of pediatric oncology, radiation therapy, surgery, pathology, nursing, supportive care, diagnostic imaging, and data management. This proposal for participation of CMH and its affiliates (Rush-Presbyterian St. Luke's Medical Center (RPSLMC), Cook County Hospital (CCH), and Christ Hospital (CH)] will ensure access of the majority of children diagnosed with malignancies in the greater Chicagoland area to clinical protocols of the POG. The proposal will furthermore provide for the mechanism for attendance and major participation of investigators in group meetings, scientific and developmental activities, committees, specific protocols, administrative and other clinical research activities for the Group.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
5U10CA007431-30
Application #
3555897
Study Section
Cancer Clinical Investigation Review Committee (CCI)
Project Start
1978-12-01
Project End
1995-12-31
Budget Start
1993-01-15
Budget End
1993-12-31
Support Year
30
Fiscal Year
1993
Total Cost
Indirect Cost

  Institution

Name
Children's Memorial Hospital (Chicago)
Department
Type
DUNS #
City
Chicago
State
IL
Country
United States
Zip Code
60611

  Publications

Wacker, Pierre; Land, Vita J; Camitta, Bruce M et al. (2007) Allergic reactions to E. coli L-asparaginase do not affect outcome in childhood B-precursor acute lymphoblastic leukemia: a Children's Oncology Group Study. J Pediatr Hematol Oncol 29:627-32
Ravindranath, Y; Chang, M; Steuber, C P et al. (2005) Pediatric Oncology Group (POG) studies of acute myeloid leukemia (AML): a review of four consecutive childhood AML trials conducted between 1981 and 2000. Leukemia 19:2101-16
Shamberger, Robert C; LaQuaglia, Michael P; Gebhardt, Mark C et al. (2003) Ewing sarcoma/primitive neuroectodermal tumor of the chest wall: impact of initial versus delayed resection on tumor margins, survival, and use of radiation therapy. Ann Surg 238:563-7; discussion 567-8
Pollock, Brad H; Jenson, Hal B; Leach, Charles T et al. (2003) Risk factors for pediatric human immunodeficiency virus-related malignancy. JAMA 289:2393-9
Davies, Stella M; Bhatia, Smita; Ross, Julie A et al. (2002) Glutathione S-transferase genotypes, genetic susceptibility, and outcome of therapy in childhood acute lymphoblastic leukemia. Blood 100:67-71
Mitchell, Claudia; Fausto, Nelson (2002) Bone marrow-derived hepatocytes : rare but promising. Am J Pathol 161:349-50
Lacayo, N J; Lum, B L; Becton, D L et al. (2002) Pharmacokinetic interactions of cyclosporine with etoposide and mitoxantrone in children with acute myeloid leukemia. Leukemia 16:920-7
Ferguson, W S; Harris, M B; Goorin, A M et al. (2001) Presurgical window of carboplatin and surgery and multidrug chemotherapy for the treatment of newly diagnosed metastatic or unresectable osteosarcoma: Pediatric Oncology Group Trial. J Pediatr Hematol Oncol 23:340-8
Saylors 3rd, R L; Stine, K C; Sullivan, J et al. (2001) Cyclophosphamide plus topotecan in children with recurrent or refractory solid tumors: a Pediatric Oncology Group phase II study. J Clin Oncol 19:3463-9
Hurwitz, C A; Strauss, L C; Kepner, J et al. (2001) Paclitaxel for the treatment of progressive or recurrent childhood brain tumors: a pediatric oncology phase II study. J Pediatr Hematol Oncol 23:277-81

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