The cooperative research efforts of the 63 Pediatric Oncology Group (POG) member and affiliate institutions are contributing significantly to the advancement of knowledge concerning the biology and therapy of most types of childhood malignancies. The University of Mississippi utilizes the cooperative protocols of the POG as the foundation for its clinical and laboratory research programs in pediatric oncology. The University of Mississippi Medical Center (UMC) and USAF Medical Center Keesler are the only centers on the state providing comprehensive care for children with cancer. The UMC's participation in the POG incorporates the multidisciplinary input of pediatric medical oncology (chemotherapy), pediatric surgery, pediatric pathology, radiotherapy, immunology, and cytogenetics both locally and in scientific and administrative activities for the group. The UMC serves as the coordinating institution for the pilot (POG 7865/7866) and currently active (POG 8035/8036) ALinC 13 classification (C) and treatment (T) studies for patients with newly diagnosed acute lymphocytic leukemia (ALL). The UMC is also coordinating the classification study (POG 8305) for ALL patients in initial relapse and will cooordinate the classification portion of the ALinC 14 study when it is activated. In coordinating the POG's ALL classification studies, the UMC is participating with the POG Statistical Office in a project to study the efficacy of utilizing microcomputer transfer of data from the study coordinator's office to the POG central computer data base. As chairman of the New ALL Subcommittee the UMC principal investigator is helping to direct the planning of the POG ALinC 14 studies and the new T-cell leukemia protocol. UMC personnel are also participating in the committees for the planning of new protocols for brian tumor and Hodgkin's disease.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
5U10CA015989-14
Application #
3556346
Study Section
Cancer Clinical Investigation Review Committee (CCI)
Project Start
1979-01-01
Project End
1990-12-31
Budget Start
1988-01-01
Budget End
1988-12-31
Support Year
14
Fiscal Year
1988
Total Cost
Indirect Cost
Name
University of Mississippi Medical Center
Department
Type
Schools of Medicine
DUNS #
928824473
City
Jackson
State
MS
Country
United States
Zip Code
39216
Wacker, Pierre; Land, Vita J; Camitta, Bruce M et al. (2007) Allergic reactions to E. coli L-asparaginase do not affect outcome in childhood B-precursor acute lymphoblastic leukemia: a Children's Oncology Group Study. J Pediatr Hematol Oncol 29:627-32
Whitehead, V M; Shuster, J J; Vuchich, M J et al. (2005) Accumulation of methotrexate and methotrexate polyglutamates in lymphoblasts and treatment outcome in children with B-progenitor-cell acute lymphoblastic leukemia: a Pediatric Oncology Group study. Leukemia 19:533-6
Shamberger, Robert C; LaQuaglia, Michael P; Gebhardt, Mark C et al. (2003) Ewing sarcoma/primitive neuroectodermal tumor of the chest wall: impact of initial versus delayed resection on tumor margins, survival, and use of radiation therapy. Ann Surg 238:563-7; discussion 567-8
Goorin, Allen M; Harris, Michael B; Bernstein, Mark et al. (2002) Phase II/III trial of etoposide and high-dose ifosfamide in newly diagnosed metastatic osteosarcoma: a pediatric oncology group trial. J Clin Oncol 20:426-33
Winter, S S; Sweatman, J; Shuster, J J et al. (2002) Bone marrow stroma-supported culture of T-lineage acute lymphoblastic leukemic cells predicts treatment outcome in children: a Pediatric Oncology Group study. Leukemia 16:1121-6
Mahoney Jr, D H; Cohen, M E; Friedman, H S et al. (2000) Carboplatin is effective therapy for young children with progressive optic pathway tumors: a Pediatric Oncology Group phase II study. Neuro Oncol 2:213-20
Pullen, J; Shuster, J J; Link, M et al. (1999) Significance of commonly used prognostic factors differs for children with T cell acute lymphocytic leukemia (ALL), as compared to those with B-precursor ALL. A Pediatric Oncology Group (POG) study. Leukemia 13:1696-707
Borowitz, M J; Rubnitz, J; Nash, M et al. (1998) Surface antigen phenotype can predict TEL-AML1 rearrangement in childhood B-precursor ALL: a Pediatric Oncology Group study. Leukemia 12:1764-70
Camitta, B M; Pullen, J; Murphy, S (1997) Biology and treatment of acute lymphocytic leukemia in children. Semin Oncol 24:83-91
Martin, P L; Look, A T; Schnell, S et al. (1996) Comparison of fluorescence in situ hybridization, cytogenetic analysis, and DNA index analysis to detect chromosomes 4 and 10 aneuploidy in pediatric acute lymphoblastic leukemia: a Pediatric Oncology Group study. J Pediatr Hematol Oncol 18:113-21

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