The overall goal of the ECOG Operations Office is to provide leadership and support for multi disciplinary clinical trials designed to improve cancer therapy. To achieve this the specific aims are as follows: A. Improving clinical trials efficiency by diminishing lag times in protocol development, forms development, and protocol review; developing (computer) on-line randomization access and checklists; and eliminating unnecessary requirements for registration, on study requirements and follow up measurements. B. Initiating new scientific thrusts by incorporating into our clinical trials elements of modern cancer biology, including biologic response modifier agents, growth factors, immunochemistry, molecular probes for oncogenes, and cytogenetics. C. Providing resources to our MOC and DOC chairs to support protocol development, to initiate implementation of laboratory projects, to monitor the conduct of trials, and to plan for new studies. D. Enhancing the accrual of patients into major protocols such as the NCI high priority initiatives, Phase 3 trials and Genitourinary cancers by providing administrative and fiscal support to enlist patients from new or established participants.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
5U10CA021115-19
Application #
3556595
Study Section
Cancer Clinical Investigation Review Committee (CCI)
Project Start
1992-09-01
Project End
1994-06-30
Budget Start
1993-05-06
Budget End
1994-06-30
Support Year
19
Fiscal Year
1993
Total Cost
Indirect Cost
Name
Amc Cancer Research Center
Department
Type
DUNS #
City
Denver
State
CO
Country
United States
Zip Code
80214
Lubner, Sam; Feng, Yang; Mulcahy, Mary et al. (2018) E4206: AMG 706 and Octreotide in Patients with Low-Grade Neuroendocrine Tumors. Oncologist 23:1006-e104
Moots, Paul L; O'Neill, Anne; Londer, Harold et al. (2018) Preradiation Chemotherapy for Adult High-risk Medulloblastoma: A Trial of the ECOG-ACRIN Cancer Research Group (E4397). Am J Clin Oncol 41:588-594
Ignatz-Hoover, James J; Wang, Victoria; Mackowski, Nathan M et al. (2018) Aberrant GSK3? nuclear localization promotes AML growth and drug resistance. Blood Adv 2:2890-2903
Gravis, Gwenaelle; Boher, Jean-Marie; Chen, Yu-Hui et al. (2018) Burden of Metastatic Castrate Naive Prostate Cancer Patients, to Identify Men More Likely to Benefit from Early Docetaxel: Further Analyses of CHAARTED and GETUG-AFU15 Studies. Eur Urol 73:847-855
Francis, Prudence A; Pagani, Olivia; Fleming, Gini F et al. (2018) Tailoring Adjuvant Endocrine Therapy for Premenopausal Breast Cancer. N Engl J Med 379:122-137
Lemieux, Julie; Brundage, Michael D; Parulekar, Wendy R et al. (2018) Quality of Life From Canadian Cancer Trials Group MA.17R: A Randomized Trial of Extending Adjuvant Letrozole to 10 Years. J Clin Oncol 36:563-571
Ailawadhi, Sikander; Jacobus, Susanna; Sexton, Rachael et al. (2018) Disease and outcome disparities in multiple myeloma: exploring the role of race/ethnicity in the Cooperative Group clinical trials. Blood Cancer J 8:67
Sebastian, Sinto; Zhu, Yuan X; Braggio, Esteban et al. (2017) Multiple myeloma cells' capacity to decompose H2O2 determines lenalidomide sensitivity. Blood 129:991-1007
Erbe, Amy K; Wang, Wei; Goldberg, Jacob et al. (2017) FCGR Polymorphisms Influence Response to IL2 in Metastatic Renal Cell Carcinoma. Clin Cancer Res 23:2159-2168
Holstein, Sarah A; Jung, Sin-Ho; Richardson, Paul G et al. (2017) Updated analysis of CALGB (Alliance) 100104 assessing lenalidomide versus placebo maintenance after single autologous stem-cell transplantation for multiple myeloma: a randomised, double-blind, phase 3 trial. Lancet Haematol 4:e431-e442

Showing the most recent 10 out of 753 publications