Since 1979, the University of Alabama at Birmingham (UAB) has actively participated in the ongoing clinical and basic research studies of the Pediatric Oncology Group (POG). UAB has provided leadership in POG through participation in Phase II and III therapeutic trials employing multi-modality treatments (surgery, chemotherapy, and radiotherapy), through participation in and designing of biological studies in a variety of hematopoietic and solid malignancies, through the development and coordination of therapeutic trials, and by providing disease committee and administrative leadership within the Group. Investigators at UAB have also participated in pilot studies used to generate front-line therapeutic trials in POG. A summary of current results of POG trials and the POG bibliography are available in the Progress Report. UAB will continue to place all eligible patients on active therapeutic and biological studies. Furthermore, UAB investigators will develop studies for the treatment of relapsing and newly diagnosed high risk neuroblastoma, for using 13-cis retinoic acid in juvenile chronic myelogenous leukemia (JCML), for the biological assessment and clinical management of children with primitive neuro-ectodermal tumor (PNET), for evaluating the use of cytokines in therapeutic trials, and for standardizing the management of children with chemotherapy-induced neutropenia and fever. UAB has also applied to become a member of the phase I working group of POG and as such to participate in POG phase I trials. In collaboration with investigators at the UAB Comprehensive Cancer Center and the Southern Research Institute in Birmingham, UAB will investigate new drugs which are potential candidates for group-wide studies. UAB will continue to provide reference/research laboratories for POG in the following areas: 1) Cytogenetic assessment of newly diagnosed patients with lymphoid and myeloid leukemias; 2) A required neuroblastoma serum/plasma repository '(POG #9047) with clinical and demographic data referenced in a computer data base; 3) A required reference laboratory (POG #8823/24) for children with adult and juvenile chronic myelogenous leukemia; 4) A non-mandatory reference laboratory for the study of microtubular associated proteins (MAPs) and tubulin isotypes in neuroblastoma.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
5U10CA025408-14
Application #
3556752
Study Section
Cancer Clinical Investigation Review Committee (CCI)
Project Start
1979-03-01
Project End
1995-12-31
Budget Start
1992-01-01
Budget End
1992-12-31
Support Year
14
Fiscal Year
1992
Total Cost
Indirect Cost
Name
University of Alabama Birmingham
Department
Type
Schools of Medicine
DUNS #
004514360
City
Birmingham
State
AL
Country
United States
Zip Code
35294
Henderson, Tara O; Bhatia, Smita; Pinto, Navin et al. (2011) Racial and ethnic disparities in risk and survival in children with neuroblastoma: a Children's Oncology Group study. J Clin Oncol 29:76-82
Schneiderman, Jennifer; London, Wendy B; Brodeur, Garrett M et al. (2008) Clinical significance of MYCN amplification and ploidy in favorable-stage neuroblastoma: a report from the Children's Oncology Group. J Clin Oncol 26:913-8
Wacker, Pierre; Land, Vita J; Camitta, Bruce M et al. (2007) Allergic reactions to E. coli L-asparaginase do not affect outcome in childhood B-precursor acute lymphoblastic leukemia: a Children's Oncology Group Study. J Pediatr Hematol Oncol 29:627-32
Moreau, Lisa A; McGrady, Patrick; London, Wendy B et al. (2006) Does MYCN amplification manifested as homogeneously staining regions at diagnosis predict a worse outcome in children with neuroblastoma? A Children's Oncology Group study. Clin Cancer Res 12:5693-7
Whitehead, V M; Shuster, J J; Vuchich, M J et al. (2005) Accumulation of methotrexate and methotrexate polyglutamates in lymphoblasts and treatment outcome in children with B-progenitor-cell acute lymphoblastic leukemia: a Pediatric Oncology Group study. Leukemia 19:533-6
George, Rani E; London, Wendy B; Cohn, Susan L et al. (2005) Hyperdiploidy plus nonamplified MYCN confers a favorable prognosis in children 12 to 18 months old with disseminated neuroblastoma: a Pediatric Oncology Group study. J Clin Oncol 23:6466-73
Ravindranath, Y; Chang, M; Steuber, C P et al. (2005) Pediatric Oncology Group (POG) studies of acute myeloid leukemia (AML): a review of four consecutive childhood AML trials conducted between 1981 and 2000. Leukemia 19:2101-16
Goorin, Allen M; Schwartzentruber, Douglas J; Devidas, Meenakshi et al. (2003) Presurgical chemotherapy compared with immediate surgery and adjuvant chemotherapy for nonmetastatic osteosarcoma: Pediatric Oncology Group Study POG-8651. J Clin Oncol 21:1574-80
Shamberger, Robert C; LaQuaglia, Michael P; Gebhardt, Mark C et al. (2003) Ewing sarcoma/primitive neuroectodermal tumor of the chest wall: impact of initial versus delayed resection on tumor margins, survival, and use of radiation therapy. Ann Surg 238:563-7; discussion 567-8
Maris, John M; Castleberry, Robert P (2003) Chemotherapy for neuroblastoma: is it all or none? J Pediatr Hematol Oncol 25:512-4

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