Abstract

The overall objective of this proposal is to improve the diagnosis, treatment and rehabilitation of children with cancer through participation in protocols designed by Children's Cancer Study Group, a mission similar to the objective of Children's Cancer Study Group. The Children's Hospital Medical Center is the major pediatric center within a 50-75 mile radius of Cincinnati and is the only pediatric unit within Cincinnati. The University of Kentucky Medical Center which is 85 miles from Cincinnati; collaborates with Children Hospital Medical Center in a multidisciplinary approach to the diagnosis, treatment and investigation of children with cancer. The members of the team at both institutions include: hematologist/oncologists, surgeons, radiologists, radiotherapists, pathologists, nuclear medicine physicians and biochemists. The research plan for participation in Children's Cancer Study Group by both Children's Hospital Medical Center and the University of Kentucky Medical Center consists of (a) participation by entering patients on protocols, (b) participation on committees to write protocols, (c) education of medical and paramedical personnel regarding cooperative studies in children with cancer, and (d) independent research in the field of cell kinetics, biochemistry and immunology. Participation by Children's Hospital Medical Center and the University of Kentucky Medical Center in Children's Cancer Study Group should improve the diagnosis, treatment and rehabilitation of children with cancer in the referral areas of the two institutions. The results of on-going research programs at both institutions may serve as a background for group-wide application.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
5U10CA026126-08
Application #
3556801
Study Section
Cancer Clinical Investigation Review Committee (CCI)
Project Start
1979-07-01
Project End
1988-11-30
Budget Start
1985-12-01
Budget End
1986-11-30
Support Year
8
Fiscal Year
1986
Total Cost
Indirect Cost

  Institution

Name
Cincinnati Children's Hospital Medical Center
Department
Type
DUNS #
071284913
City
Cincinnati
State
OH
Country
United States
Zip Code
45229

  Publications

Neudorf, Steven; Sanders, Jean; Kobrinsky, Nathan et al. (2004) Allogeneic bone marrow transplantation for children with acute myelocytic leukemia in first remission demonstrates a role for graft versus leukemia in the maintenance of disease-free survival. Blood 103:3655-61
Shamberger, Robert C; LaQuaglia, Michael P; Gebhardt, Mark C et al. (2003) Ewing sarcoma/primitive neuroectodermal tumor of the chest wall: impact of initial versus delayed resection on tumor margins, survival, and use of radiation therapy. Ann Surg 238:563-7; discussion 567-8
Casillas, Jacqueline N; Woods, William G; Hunger, Stephen P et al. (2003) Prognostic implications of t(10;11) translocations in childhood acute myelogenous leukemia: a report from the Children's Cancer Group. J Pediatr Hematol Oncol 25:594-600
Davies, Stella M; Bhatia, Smita; Ross, Julie A et al. (2002) Glutathione S-transferase genotypes, genetic susceptibility, and outcome of therapy in childhood acute lymphoblastic leukemia. Blood 100:67-71
Wells, Robert J; Reid, Joel M; Ames, Matthew M et al. (2002) Phase I trial of cisplatin and topotecan in children with recurrent solid tumors: Children's Cancer Group Study 0942. J Pediatr Hematol Oncol 24:89-93
Lange, Beverly J; Bostrom, Bruce C; Cherlow, Joel M et al. (2002) Double-delayed intensification improves event-free survival for children with intermediate-risk acute lymphoblastic leukemia: a report from the Children's Cancer Group. Blood 99:825-33
Ou, Shu Xiao; Han, Dehui; Severson, Richard K et al. (2002) Birth characteristics, maternal reproductive history, hormone use during pregnancy, and risk of childhood acute lymphocytic leukemia by immunophenotype (United States). Cancer Causes Control 13:15-25
Cairo, M S; Krailo, M D; Morse, M et al. (2002) Long-term follow-up of short intensive multiagent chemotherapy without high-dose methotrexate ('Orange') in children with advanced non-lymphoblastic non-Hodgkin's lymphoma: a children's cancer group report. Leukemia 16:594-600
Wells, R J; Arthur, D C; Srivastava, A et al. (2002) Prognostic variables in newly diagnosed children and adolescents with acute myeloid leukemia: Children's Cancer Group Study 213. Leukemia 16:601-7
Arndt, C A; Krailo, M D; Liu-Mares, W et al. (2001) Phase I study of CI-958 in children and adolescents with recurrent solid tumors. Cancer 91:1166-9

Showing the most recent 10 out of 17 publications