The UCLA Medical Center multidisciplinary team is committed to the CCG research effort in pediatric oncology Over the 15 years of our CCG membership, the UCLA team has grown progressively. The entire team has expanded to include 42 physician investigators (including 6 pediatric oncologists), 5 Ph.D.'s, and 2 research nurses at the primary institution. UCLA investigators have held positions of scientific leadership in CCG studies of ALL, AML, Neuroblastoma, and Bone Marrow Transplantation. The disciplines in which the expertise of UCLA team members has been employed by CCG are in pediatric oncology, allogeneic and autologous bone marrow transplantation, nursing, psychology, and radiation oncology. UCLA's entry of patients into CCG studies has increased progressively over the years. We expect this trend to continue, as a result of an expanding referral pattern and the growth of our affiliate network. UCLA investigators will continue to provide leadership in the studies of childhood leukemia and the growing application of bone marrow transplantation to the treatment of pediatric malignancies. We will continue our leadership of the assessment of late neuropsychologic sequelae and in nursing studies. The development of a program in stereotactic cerebral radiation therapy at UCLA will add another area of innovative CCG leadership. A new program in cancer control has been added which seeks to diminish the risk of late second cancers among survivors of pediatric cancer. UCLA pediatric oncology basic research programs have grown progressively over the last 5 years. We have active and productive laboratory investigations in the biology of neuroblastoma, Ewings Sarcoma, regulation of B-cell differentiation and hematopoietic growth factors. Progress in these projects will offer several new opportunities to apply our fundamental observations to the understanding, diagnosis, and treatment of pediatric cancers in CCG biologic and therapeutic studies.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
5U10CA027678-16
Application #
2087628
Study Section
Cancer Clinical Investigation Review Committee (CCI)
Project Start
1980-12-01
Project End
1998-11-30
Budget Start
1994-12-01
Budget End
1995-11-30
Support Year
16
Fiscal Year
1995
Total Cost
Indirect Cost
Name
University of California Los Angeles
Department
Pediatrics
Type
Schools of Medicine
DUNS #
119132785
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Neudorf, Steven; Sanders, Jean; Kobrinsky, Nathan et al. (2004) Allogeneic bone marrow transplantation for children with acute myelocytic leukemia in first remission demonstrates a role for graft versus leukemia in the maintenance of disease-free survival. Blood 103:3655-61
Seitzman, Robin L; Glover, Dorie A; Meadows, Anna T et al. (2004) Self-concept in adult survivors of childhood acute lymphoblastic leukemia: a cooperative Children's Cancer Group and National Institutes of Health study. Pediatr Blood Cancer 42:230-40
Shamberger, Robert C; LaQuaglia, Michael P; Gebhardt, Mark C et al. (2003) Ewing sarcoma/primitive neuroectodermal tumor of the chest wall: impact of initial versus delayed resection on tumor margins, survival, and use of radiation therapy. Ann Surg 238:563-7; discussion 567-8
Davies, Stella M; Bhatia, Smita; Ross, Julie A et al. (2002) Glutathione S-transferase genotypes, genetic susceptibility, and outcome of therapy in childhood acute lymphoblastic leukemia. Blood 100:67-71
Lange, Beverly J; Bostrom, Bruce C; Cherlow, Joel M et al. (2002) Double-delayed intensification improves event-free survival for children with intermediate-risk acute lymphoblastic leukemia: a report from the Children's Cancer Group. Blood 99:825-33
Ou, Shu Xiao; Han, Dehui; Severson, Richard K et al. (2002) Birth characteristics, maternal reproductive history, hormone use during pregnancy, and risk of childhood acute lymphocytic leukemia by immunophenotype (United States). Cancer Causes Control 13:15-25
Cairo, M S; Krailo, M D; Morse, M et al. (2002) Long-term follow-up of short intensive multiagent chemotherapy without high-dose methotrexate ('Orange') in children with advanced non-lymphoblastic non-Hodgkin's lymphoma: a children's cancer group report. Leukemia 16:594-600
Wells, R J; Arthur, D C; Srivastava, A et al. (2002) Prognostic variables in newly diagnosed children and adolescents with acute myeloid leukemia: Children's Cancer Group Study 213. Leukemia 16:601-7
Cooper, R; Khakoo, Y; Matthay, K K et al. (2001) Opsoclonus-myoclonus-ataxia syndrome in neuroblastoma: histopathologic features-a report from the Children's Cancer Group. Med Pediatr Oncol 36:623-9
Meyers, P A; Krailo, M D; Ladanyi, M et al. (2001) High-dose melphalan, etoposide, total-body irradiation, and autologous stem-cell reconstitution as consolidation therapy for high-risk Ewing's sarcoma does not improve prognosis. J Clin Oncol 19:2812-20

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