The general aim of this research plan is to improve the treatment of childhood cancer through participation in organized clinical trials with fellow members of the Pediatric Oncology Group as well as to improve our understanding of the diseases with collaborative laboratory investigations. This portion of the application includes a description of the institutional activities at Johns Hopkins. The program is divided into Pediatrics the program which describes the patient accrual and protocol activity within Johns Hopkins Pediatric Oncology division per se under the direction of Dr. Leventhal as well as the patient activity at Fairfax Hospital which has been a satellite of Johns Hopkins for 3 years. The work of individual faculty members as protocol coordinators for the POG is also described here. The University of Maryland will become a satellite of Johns Hopkins in July, 1990 when Dr. Christopher Frantz arrives in Baltimore to head that institution. This program is described separately but will be funded as a contract from Johns Hopkins. At Johns Hopkins, the programs in Radiation Oncology, Pediatric Surgery, Pathology and Neurooncology are also described along with their participation in the patient accrual and protocol activity of the Pediatric Oncology Group. The multiplicity of projects, we fell, -reflects the intense commitment of our faculty to our work within the Pediatric Oncology Group. With the small numbers of patients admitted with any single diagnosis to an individual institution, it is clear that cooperative clinical research is required if significant advances are to be made.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Cooperative Clinical Research--Cooperative Agreements (U10)
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Cancer Clinical Investigation Review Committee (CCI)
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Johns Hopkins University
Schools of Medicine
United States
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Wacker, Pierre; Land, Vita J; Camitta, Bruce M et al. (2007) Allergic reactions to E. coli L-asparaginase do not affect outcome in childhood B-precursor acute lymphoblastic leukemia: a Children's Oncology Group Study. J Pediatr Hematol Oncol 29:627-32
Kung, Faith H; Schwartz, Cindy L; Ferree, Carolyn R et al. (2006) POG 8625: a randomized trial comparing chemotherapy with chemoradiotherapy for children and adolescents with Stages I, IIA, IIIA1 Hodgkin Disease: a report from the Children's Oncology Group. J Pediatr Hematol Oncol 28:362-8
Ravindranath, Y; Chang, M; Steuber, C P et al. (2005) Pediatric Oncology Group (POG) studies of acute myeloid leukemia (AML): a review of four consecutive childhood AML trials conducted between 1981 and 2000. Leukemia 19:2101-16
Shamberger, Robert C; LaQuaglia, Michael P; Gebhardt, Mark C et al. (2003) Ewing sarcoma/primitive neuroectodermal tumor of the chest wall: impact of initial versus delayed resection on tumor margins, survival, and use of radiation therapy. Ann Surg 238:563-7; discussion 567-8
Goorin, Allen M; Schwartzentruber, Douglas J; Devidas, Meenakshi et al. (2003) Presurgical chemotherapy compared with immediate surgery and adjuvant chemotherapy for nonmetastatic osteosarcoma: Pediatric Oncology Group Study POG-8651. J Clin Oncol 21:1574-80
Goorin, Allen M; Harris, Michael B; Bernstein, Mark et al. (2002) Phase II/III trial of etoposide and high-dose ifosfamide in newly diagnosed metastatic osteosarcoma: a pediatric oncology group trial. J Clin Oncol 20:426-33
Laver, Joseph H; Mahmoud, Hazem; Pick, Terry E et al. (2002) Results of a randomized phase III trial in children and adolescents with advanced stage diffuse large cell non-Hodgkin's lymphoma: a Pediatric Oncology Group study. Leuk Lymphoma 43:105-9
Bell, B A; Chang, M N; Weinstein, H J (2001) A phase II study of Homoharringtonine for the treatment of children with refractory or recurrent acute myelogenous leukemia: a pediatric oncology group study. Med Pediatr Oncol 37:103-7
Saylors 3rd, R L; Stine, K C; Sullivan, J et al. (2001) Cyclophosphamide plus topotecan in children with recurrent or refractory solid tumors: a Pediatric Oncology Group phase II study. J Clin Oncol 19:3463-9
Hu, J; Schuster, A E; Fritsch, M K et al. (2001) Deletion mapping of 6q21-26 and frequency of 1p36 deletion in childhood endodermal sinus tumors by microsatellite analysis. Oncogene 20:8042-4

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