The major objective of the Statistical Center for Pediatric Intergroup Studies is to provide comprehensive and efficient statistical services to clinicians conducting Intergroup Studies in Rhabdomyosarcoma. These services include: review and input concerning biostatistical aspects of all protocols; registration and randomization of patients on study; surveillance, monitoring, storage and processing of data collected during studies; review and evaluation of endpoints and the performance of patients on studies; analyses and reports of ongoing and completed studies; and cooperation with clinical investigators in writing scientific papers and reporting clinical research projects. Continuing statistical services will be provided for the conduct of Intergroup Rhabdomyosarcoma III which began in November, 1984 and 835 eligible patients had been entered as of September, 1988. Some stratifications of patients have been closed and the remaining ones are expected to be closed during 1989 or early 1990. Statistical services will be provided for pilot studies which have been planned to guide Intergroup Rhabdomyosarcoma Study IV, which is expected to open in 1990. Also, analyses and reports will be prepared in cooperation with clinicians to investigate various aspects of completed studies, such as the prognosis of patients in certain primary sites. A repository of data will be maintained for patients entered into completed intergroup studies of Ewing's sarcoma and Hodgkin's disease. Non-metastatic and metastatic Ewing's sarcoma patients were entered into studies that were conducted between 1972 and 1983. Pediatric patients with Hodgkin's disease (Stages I and II) were entered into a clinical study conducted between 1977 and 1981. Data from these studies will be maintained for the purpose of preparing special reports, such as prognostic factors studies and studies of the late effects of therapy.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Cooperative Clinical Research--Cooperative Agreements (U10)
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Special Emphasis Panel (SRC (B2))
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University of Texas MD Anderson Cancer Center
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La, Trang H; Wolden, Suzanne L; Su, Zheng et al. (2011) Local therapy for rhabdomyosarcoma of the hands and feet: is amputation necessary? A report from the Children's Oncology Group. Int J Radiat Oncol Biol Phys 80:206-12
La, Trang H; Wolden, Suzanne L; Rodeberg, David A et al. (2011) Regional nodal involvement and patterns of spread along in-transit pathways in children with rhabdomyosarcoma of the extremity: a report from the Children's Oncology Group. Int J Radiat Oncol Biol Phys 80:1151-7
Minn, A Yuriko; Lyden, Elizabeth R; Anderson, James R et al. (2010) Early treatment failure in intermediate-risk rhabdomyosarcoma: results from IRS-IV and D9803--a report from the Children's Oncology Group. J Clin Oncol 28:4228-32
Wharam, Moody D; Meza, Jane; Anderson, James et al. (2004) Failure pattern and factors predictive of local failure in rhabdomyosarcoma: a report of group III patients on the third Intergroup Rhabdomyosarcoma Study. J Clin Oncol 22:1902-8
Breneman, John C; Lyden, Elizabeth; Pappo, Alberto S et al. (2003) Prognostic factors and clinical outcomes in children and adolescents with metastatic rhabdomyosarcoma--a report from the Intergroup Rhabdomyosarcoma Study IV. J Clin Oncol 21:78-84
Baker, K Scott; Anderson, James R; Lobe, Thom E et al. (2002) Children from ethnic minorities have benefited equally as other children from contemporary therapy for rhabdomyosarcoma: a report from the Intergroup Rhabdomyosarcoma Study Group. J Clin Oncol 20:4428-33
Crist, W M; Anderson, J R; Meza, J L et al. (2001) Intergroup rhabdomyosarcoma study-IV: results for patients with nonmetastatic disease. J Clin Oncol 19:3091-102
Baker, K S; Anderson, J R; Link, M P et al. (2000) Benefit of intensified therapy for patients with local or regional embryonal rhabdomyosarcoma: results from the Intergroup Rhabdomyosarcoma Study IV. J Clin Oncol 18:2427-34
Raney, R B; Asmar, L; Vassilopoulou-Sellin, R et al. (1999) Late complications of therapy in 213 children with localized, nonorbital soft-tissue sarcoma of the head and neck: A descriptive report from the Intergroup Rhabdomyosarcoma Studies (IRS)-II and - III. IRS Group of the Children's Cancer Group and the Pedia Med Pediatr Oncol 33:362-71
Smith, M A; Rubinstein, L; Anderson, J R et al. (1999) Secondary leukemia or myelodysplastic syndrome after treatment with epipodophyllotoxins. J Clin Oncol 17:569-77

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