The RTOG Statistical Unit was established to collaborate with RTOG investigators in defining the optimum role of radiation therapy, either alone or in combination with other modalities. These efforts should lead to improved local control, enhanced quality of life, extended survival, and an ultimate cure. To achieve this objective, the statistical unit collaborates with RTOG investigators in conducting multicenter randomized and nonrandomized clinical trials to evaluate the safety and efficacy of radiation therapy, either alone or in combination with surgery, chemotherapy and/or immunotherapy, in the treatment of patients with cancer. The RTOG statisticians work with the RTOG investigators to develop and implement research strategies for execution of a series of well- designed trials. They assure that the role of each individual modality receives adequate Phase I/II evaluation. The results can then be incorporated into designing subsequent Phase III/multidisciplinary trials with minimal delay, a minimum but sufficient number of patients, and a maximum chance of detecting clinically significant differences. The RTOG statisticians further collaborate with RTOG investigators in carefully monitoring ongoing trials, performing timely and appropriate analyses, and promptly reporting the results. The RTOG Statistical Unit determines randomization schemes and develops systems for processing and analyzing the clinical data bases. RTOG plans to expand its focus to include laboratory studies in cancer diagnostics. These studies should produce important correlations between specific tumor cell parameters and response to treatment. Given these findings, treatments can be more logically planned for individual patients. The RTOG Statistical Unit will provide the same high level of collaboration with RTOG investigators in the design, monitoring, and analysis of these laboratory studies.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
5U10CA032115-14
Application #
2088297
Study Section
Cancer Clinical Investigation Review Committee (CCI)
Project Start
1982-04-15
Project End
1996-12-31
Budget Start
1995-01-01
Budget End
1995-12-31
Support Year
14
Fiscal Year
1995
Total Cost
Indirect Cost
Name
American College of Radiology
Department
Type
DUNS #
City
Philadelphia
State
VA
Country
United States
Zip Code
Li, Donghui; Moughan, Jennifer; Crane, Christopher et al. (2016) RECQ1 A159C Polymorphism Is Associated With Overall Survival of Patients With Resected Pancreatic Cancer: A Replication Study in NRG Oncology Radiation Therapy Oncology Group 9704. Int J Radiat Oncol Biol Phys 94:554-60
Hamstra, Daniel A; Bae, Kyounghwa; Hanks, Gerald et al. (2015) Impact of biochemical failure classification on clinical outcome: a secondary analysis of Radiation Therapy Oncology Group 9202 and 9413. Cancer 121:844-52
Ben-Josef, Edgar; George, Asha; Regine, William F et al. (2015) Glycogen Synthase Kinase 3 Beta Predicts Survival in Resected Adenocarcinoma of the Pancreas. Clin Cancer Res 21:5612-8
Hsu, I-Chow; Hunt, Daniel; Straube, William et al. (2014) Dosimetric analysis of radiation therapy oncology group 0321: the importance of urethral dose. Pract Radiat Oncol 4:27-34
Xiao, Canhua; Hanlon, Alexandra; Zhang, Qiang et al. (2014) Risk factors for clinician-reported symptom clusters in patients with advanced head and neck cancer in a phase 3 randomized clinical trial: RTOG 0129. Cancer 120:848-54
Cairncross, J Gregory; Wang, Meihua; Jenkins, Robert B et al. (2014) Benefit from procarbazine, lomustine, and vincristine in oligodendroglial tumors is associated with mutation of IDH. J Clin Oncol 32:783-90
Komaki, Ritsuko; Paulus, Rebecca; Blumenschein Jr, George R et al. (2014) EGFR expression and survival in patients given cetuximab and chemoradiation for stage III non-small cell lung cancer: a secondary analysis of RTOG 0324. Radiother Oncol 112:30-6
Xiao, Canhua; Hanlon, Alexandra; Zhang, Qiang et al. (2013) Symptom clusters in patients with head and neck cancer receiving concurrent chemoradiotherapy. Oral Oncol 49:360-6
Cairncross, Gregory; Wang, Meihua; Shaw, Edward et al. (2013) Phase III trial of chemoradiotherapy for anaplastic oligodendroglioma: long-term results of RTOG 9402. J Clin Oncol 31:337-43
Lawrence, Yaacov Richard; Paulus, Rebecca; Langer, Corey et al. (2013) The addition of amifostine to carboplatin and paclitaxel based chemoradiation in locally advanced non-small cell lung cancer: long-term follow-up of Radiation Therapy Oncology Group (RTOG) randomized trial 9801. Lung Cancer 80:298-305

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