Support is requested for participation in all clinical and laboratory investigative activities of the Pediatric Oncology Group (POG). Specifically, these funds will assist our efforts in cooperative cancer therapy trials which utilize a combination of surgery and/or radiation therapy and/or chemotherapy for the treatment of leukemias, lymphomas, solid tumors and brain tumors. Emphasis will be placed on integrated multi-modality treatment programs in Phase III randomized prospective studies. We shall also participate in group-wide Phase II studies of new chemotherapeutic agents. We plan to participate fully in limited Pediatric Phase I studies of new agents. (This is the subject of a contract proposal from several POG institutions, including ourselves, to the NCI). We shall participate in studies examining the biology of various pediatric malignancies including immunologic and pharmacologic features; in studies of the late effects of therapy in surviving patients; and in epidemiological studies. Support will permit us to enter the maximum number of patients on study and ensure complete documentation of patient data, including transport of specimens to reference laboratories. It will permit members to attend POG meetings and to participate in working sub-committees, protocol planning committees and study writing committees. In addition it will permit certain investigators to continue to contribute in leadership roles to the science and administration of the POG. Dr. V. Michael Whitehead is Co-Chairman of the New Agents & Pharmacology Scientific Support Committee. In this position, he directs Phase I and Phase II new agent studies. He is developing protocols to study the pharmacology of methotrexate, 6-mercaptopurine and cytosine arabinoside in children with acute lymphoblastic leukemia. He is a member of the Planning Committee for ALinC 14, the next frontline therapeutic study of acute lymphoblastic leukemia. Dr. Carol Freeman is Coordinator of the Phase I study of Hyperfractionation in Brainstem Gliomas in Children (POG 8495) and a member of the following POG committees: Institutional Performance Review Committee and the Brain Tumor Core Committee. Dr. Penny Koch is a member of the Bone Marrow Transplant Core Committee. Susan Kajaks is a member of the Data Managers Core Committee.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
5U10CA033587-06
Application #
3557298
Study Section
Cancer Clinical Investigation Review Committee (CCI)
Project Start
1983-01-01
Project End
1990-12-31
Budget Start
1988-01-01
Budget End
1988-12-31
Support Year
6
Fiscal Year
1988
Total Cost
Indirect Cost
Name
Montreal Children's Hospital
Department
Type
DUNS #
City
Montreal
State
PQ
Country
Canada
Zip Code
Wacker, Pierre; Land, Vita J; Camitta, Bruce M et al. (2007) Allergic reactions to E. coli L-asparaginase do not affect outcome in childhood B-precursor acute lymphoblastic leukemia: a Children's Oncology Group Study. J Pediatr Hematol Oncol 29:627-32
Whitehead, V M; Shuster, J J; Vuchich, M J et al. (2005) Accumulation of methotrexate and methotrexate polyglutamates in lymphoblasts and treatment outcome in children with B-progenitor-cell acute lymphoblastic leukemia: a Pediatric Oncology Group study. Leukemia 19:533-6
Ravindranath, Y; Chang, M; Steuber, C P et al. (2005) Pediatric Oncology Group (POG) studies of acute myeloid leukemia (AML): a review of four consecutive childhood AML trials conducted between 1981 and 2000. Leukemia 19:2101-16
Shamberger, Robert C; LaQuaglia, Michael P; Gebhardt, Mark C et al. (2003) Ewing sarcoma/primitive neuroectodermal tumor of the chest wall: impact of initial versus delayed resection on tumor margins, survival, and use of radiation therapy. Ann Surg 238:563-7; discussion 567-8
Goorin, Allen M; Schwartzentruber, Douglas J; Devidas, Meenakshi et al. (2003) Presurgical chemotherapy compared with immediate surgery and adjuvant chemotherapy for nonmetastatic osteosarcoma: Pediatric Oncology Group Study POG-8651. J Clin Oncol 21:1574-80
Lacayo, N J; Lum, B L; Becton, D L et al. (2002) Pharmacokinetic interactions of cyclosporine with etoposide and mitoxantrone in children with acute myeloid leukemia. Leukemia 16:920-7
Whitehead, V M; Payment, C; Cooley, L et al. (2001) The association of the TEL-AML1 chromosomal translocation with the accumulation of methotrexate polyglutamates in lymphoblasts and with ploidy in childhood B-progenitor cell acute lymphoblastic leukemia: a Pediatric Oncology Group study. Leukemia 15:1081-8
Mahoney Jr, D H; Cohen, M E; Friedman, H S et al. (2000) Carboplatin is effective therapy for young children with progressive optic pathway tumors: a Pediatric Oncology Group phase II study. Neuro Oncol 2:213-20
Souid, A K; Fahey, R C; Dubowy, R L et al. (1999) WR-2721 (amifostine) infusion in patients with Ewing's sarcoma receiving ifosfamide and cyclophosphamide with mesna: drug and thiol levels in plasma and blood cells, a Pediatric Oncology Group study. Cancer Chemother Pharmacol 44:498-504
Bernstein, M L; Baruchel, S; Devine, S et al. (1999) Phase I and pharmacokinetic study of CI-980 in recurrent pediatric solid tumor cases: a Pediatric Oncology Group study. J Pediatr Hematol Oncol 21:494-500

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