The Duluth Clinic has worked for the past ten years to develop a multidisciplinary organization to be involved in the care of oncology patients and to function as a clinical cancer research unit for all of northeastern Minnesota, northwestern Wisconsin, the western part of the Upper Peninsula of Michigan, and has developed working relationships with the cancer clinic in Thunder Bay, Ontario. We have been members of the North Central Cancer Treatment Group since 1978 and have functioned as a CCOP organization for the last three years. During that period of time we have been active in entering patients onto clinical group protocols (515 patients entered in the last three years), and have been active in the development of new programs, as having the study chairmanship on numerous protocols and having presented material at several national meetings. All of the disciplines in oncology have been bought together under the direction of the Duluth Clinic. An excellent working relationship has been established with the Mayo Clinic through the media of the North Central Cancer Treatment Group. We have established that we have been able to generate data of unexcelled quality shown by our past performance. Geographically we feel that we are the only source for bringing benefits of clinical cancer research to the large area which we service. We will strive to continue to bring the advantages of clinical research to cancer patients in our area, and at the present time are actively increasing efforts as cancer prevention and the development of oncology rehabilitation with the help of other members of our proposed consortium. We would plan on continuing to function as a primary research base as the North Central Cancer Treatment Group with a secondary research base being the Eastern Cooperative Oncology Group and also as an affiliate member of the Cancer Children's Study Group. We hope to be able to continue to accrue approximately 200 patients per year, although with increasing number of cancer control and prevention programs being activated, this number should increase significantly, perhaps to 300 to 400 patients per year. By virtue of our already established programs and our commitment to continually improve this we feel that we can continue to be productive.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
5U10CA035269-05
Application #
3557676
Study Section
(SRC)
Project Start
1983-09-01
Project End
1990-05-31
Budget Start
1988-06-01
Budget End
1989-05-31
Support Year
5
Fiscal Year
1988
Total Cost
Indirect Cost
Name
Duluth Clinic, Ltd.
Department
Type
DUNS #
City
Duluth
State
MN
Country
United States
Zip Code
55805
Barton, Debra L; Sloan, Jeff A; Shuster, Lynne T et al. (2018) Evaluating the efficacy of vaginal dehydroepiandosterone for vaginal symptoms in postmenopausal cancer survivors: NCCTG N10C1 (Alliance). Support Care Cancer 26:643-650
Sio, Terence T; Atherton, Pamela J; Birckhead, Brandon J et al. (2016) Repeated measures analyses of dermatitis symptom evolution in breast cancer patients receiving radiotherapy in a phase 3 randomized trial of mometasone furoate vs placebo (N06C4 [alliance]). Support Care Cancer 24:3847-55
Navari, Rudolph M; Qin, Rui; Ruddy, Kathryn J et al. (2016) Olanzapine for the Prevention of Chemotherapy-Induced Nausea and Vomiting. N Engl J Med 375:134-42
Pachman, Deirdre R; Qin, Rui; Seisler, Drew et al. (2016) Comparison of oxaliplatin and paclitaxel-induced neuropathy (Alliance A151505). Support Care Cancer 24:5059-5068
Liu, Heshan; Tan, Angelina D; Qin, Rui et al. (2015) Comparing and Validating Simple Measures of Patient-Reported Peripheral Neuropathy for Oncology Clinical Trials: NCCTG N0897 (Alliance) A Pooled Analysis of 2440 Patients. SOJ Anesthesiol Pain Manag 2:
Wagner-Johnston, Nina D; Sloan, Jeff A; Liu, Heshan et al. (2015) 5-year follow-up of a randomized controlled trial of immediate versus delayed zoledronic acid for the prevention of bone loss in postmenopausal women with breast cancer starting letrozole after tamoxifen: N03CC (Alliance) trial. Cancer 121:2537-43
Dueck, A C; Singh, J; Atherton, P et al. (2015) Endpoint comparison for bone mineral density measurements in North Central Cancer Treatment Group cancer clinical trials N02C1 and N03CC (Alliance). Osteoporos Int 26:1971-7
Dronca, Roxana S; Allred, Jacob B; Perez, Domingo G et al. (2014) Phase II study of temozolomide (TMZ) and everolimus (RAD001) therapy for metastatic melanoma: a North Central Cancer Treatment Group study, N0675. Am J Clin Oncol 37:369-76
Dy, Grace K; Molina, Julian R; Qi, Yingwei et al. (2014) NCCTG N0821 (Alliance): a phase II first-line study of pemetrexed, carboplatin, and bevacizumab in elderly patients with advanced nonsquamous non-small-cell lung cancer with good performance status. J Thorac Oncol 9:1146-53
Barton, Debra L; Thanarajasingam, Gita; Sloan, Jeff A et al. (2014) Phase III double-blind, placebo-controlled study of gabapentin for the prevention of delayed chemotherapy-induced nausea and vomiting in patients receiving highly emetogenic chemotherapy, NCCTG N08C3 (Alliance). Cancer 120:3575-83

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