This application represents the first joint application of the newly formed ECOG/ACRIN alliance to build upon ECOG's long history as a successful Community Clinical Oncology Program (CCOP) Research Base. The ECOG and ACRIN leadership recognize the opportunity to strengthen their mutual scientific programs, ECOG Cancer Prevention and Control research base with ACRIN's complementary expertise in early detection, imaging diagnosis, and cost and comparative effectiveness organizations, are proposing a bold, integrated cancer prevention and control scientific program. The program will have two major foci: (1) Patient-Centered Outcomes and Survivorship and (2) Early Detection, Diagnosis and Prevention.
Specific Aims of the program: 1)To develop personalized early detection strategies to reduce false positives and improve screening outcomes;2)To contribute to state-of-the-science research in patient centered outcomes and health care related cost measurement and analysis in the context of cancer clinical trials;3)To enroll patients onto high-quality, meaningful prevention and symptom management trials that add to our understanding of the prevention or elimination of suffering attributable to cancer;4)To advance our understanding of cancer survivorship and design interventions to address related issues;5)To develop biomarker-driven chemoprevention trials based on state-of the-science preclinical data that ultimately translate into national trials through the ECOG prevention group and CCOP members;6)To continue to develop treatment protocols particularly suitable for the CCOP members of ECOG and their patients;7)To expand development of programs to increase the accrual of minority populations to ECOG trials with a focus on disparity intervention;8)To improve support for protocol development, data management, and analysis by enhancing the dedicated infrastructure within the ECOG Coordinating Center for the cancer control and prevention program to include cost effectiveness methodology;and 9)To foster collaboration between scientific committees and the Patient-Centered Outcomes and Survivorship Committee and the Early Detection, Diagnosis and Prevention Committee.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Cooperative Clinical Research--Cooperative Agreements (U10)
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Study Section
Special Emphasis Panel (ZCA1-SRLB-B (J1))
Program Officer
Brell, Joanna M
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Drexel University
Internal Medicine/Medicine
Schools of Medicine
United States
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Moots, Paul L; O'Neill, Anne; Londer, Harold et al. (2018) Preradiation Chemotherapy for Adult High-risk Medulloblastoma: A Trial of the ECOG-ACRIN Cancer Research Group (E4397). Am J Clin Oncol 41:588-594
Phipps, Amanda I; Shi, Qian; Zemla, Tyler J et al. (2018) Physical Activity and Outcomes in Patients with Stage III Colon Cancer: A Correlative Analysis of Phase III Trial NCCTG N0147 (Alliance). Cancer Epidemiol Biomarkers Prev 27:696-703
Cohee, Andrea A; Bigatti, Silvia M; Shields, Cleveland G et al. (2018) Quality of Life in Partners of Young and Old Breast Cancer Survivors. Cancer Nurs 41:491-497
Pili, Roberto; Jegede, Opeyemi; Carducci, Michael A et al. (2017) A Randomized Phase II Study to Determine the Effect of 2 Different Doses of Aflibercept in Patients With Metastatic Renal Cell Carcinoma (ECOG-ACRIN [E4805]). Clin Genitourin Cancer 15:642-651.e1
Bhatia, Aarti K; Lee, Ju-Whei; Pinto, Harlan A et al. (2017) Double-blind, randomized phase 3 trial of low-dose 13-cis retinoic acid in the prevention of second primaries in head and neck cancer: Long-term follow-up of a trial of the Eastern Cooperative Oncology Group-ACRIN Cancer Research Group (C0590). Cancer 123:4653-4662
Cohee, Andrea A; Adams, Rebecca N; Fife, Betsy L et al. (2017) Relationship Between Depressive Symptoms and Social Cognitive Processing in Partners of Long-Term Breast Cancer Survivors. Oncol Nurs Forum 44:44-51
Cohee, Andrea A; Adams, Rebecca N; Johns, Shelley A et al. (2017) Long-term fear of recurrence in young breast cancer survivors and partners. Psychooncology 26:22-28
Cohee, Andrea A; Stump, Timothy; Adams, Rebecca N et al. (2016) Factors associated with depressive symptoms in young long-term breast cancer survivors. Qual Life Res 25:1991-7
Tevaarwerk, Amye J; Lee, Ju-Whei; Terhaar, Abigail et al. (2016) Working after a metastatic cancer diagnosis: Factors affecting employment in the metastatic setting from ECOG-ACRIN's Symptom Outcomes and Practice Patterns study. Cancer 122:438-46
Fisch, Michael J; Zhao, Fengmin; Manola, Judith et al. (2015) Patterns and predictors of antidepressant use in ambulatory cancer patients with common solid tumors. Psychooncology 24:523-32

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