This application is submitted by the Cancer And Leukemia Group B (CALGB) to begin its eleventh year as a primary multi-modality Research Base for ten Community Clinical Oncology Programs (CCOPs) and one Minority-Based CCOP nine states. CALGB is a Clinical Cooperative Group with 27 Main Member institutions and a membership of about 2 health professionals at about 200 hospitals, clinics and physicians' offices in the USA, Canada & Denmark.
The Specific Aims are to provide an organized and collegial environment for community hospital health care professionals to interact with their academic counter-parts in the development and implementation of cancer prevention and control research studies and the latest cancer treatment clinical trials. CALGB proposes to enhance the translation of new information from a strong basic correlative sciences program in cancer treatment to an evolving strong program in cancer prevention and control research themes in chemoprevention, tumor markers and Psycho-Oncology. Strategies will be developed to assist CCOPs to increase accrual of minorities, women and rural underserved people into ethical, high quality clinical trials which will result in a decrease in cancer incidence, morbidity and mortality. CCOPs will be assisted in broadening their networks to include more primary health professionals and specialists to help in the diffusion of State-of- the-Art cancer care at the community level. An enhanced Continuous Quality Improvement program will be continued with audit and performance review of each institution at least every three years. There are five cancer site committees (Leukemia, Lymphoma, Respiratory, Breast and Gastrointestinal) which work closely with eleven modality committees (Pharmacology and Experimental Therapeutics, Correlative Sciences-Leukemia/Lymphoma, Correlative Sciences-Solid Tumors, Transplant, Pathology, Surgery, Radiation Oncology, Psycho-Oncology, Cancer Control, Oncology Nursing and Data Management) to plan and implement cancer prevention and treatment studies using the latest technologies and information available. These studies are designed to further our knowledge in cancer biology and therapeutics. This project will bring these advances to the community hospital level where CCOP trained health care providers can apply them immediately. An example of a cancer prevention trial that is on-going is a double-blind, placebo controlled trial of aspirin in the prevention of adenomatous polyps in subjects following curative resection of Stage I-II colorectal carcinoma.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
5U10CA037447-15
Application #
2712592
Study Section
Special Emphasis Panel (SRC (74))
Program Officer
Dunn, Barbara K
Project Start
1983-09-30
Project End
1999-05-31
Budget Start
1998-06-01
Budget End
1999-05-31
Support Year
15
Fiscal Year
1998
Total Cost
Indirect Cost
Name
University of Chicago
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
225410919
City
Chicago
State
IL
Country
United States
Zip Code
60637
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Parsons, J Kellogg; Pierce, John P; Mohler, James et al. (2018) Men's Eating and Living (MEAL) study (CALGB 70807 [Alliance]): recruitment feasibility and baseline demographics of a randomized trial of diet in men on active surveillance for prostate cancer. BJU Int 121:534-539
Holstein, Sarah A; Jung, Sin-Ho; Richardson, Paul G et al. (2017) Updated analysis of CALGB (Alliance) 100104 assessing lenalidomide versus placebo maintenance after single autologous stem-cell transplantation for multiple myeloma: a randomised, double-blind, phase 3 trial. Lancet Haematol 4:e431-e442
Basch, Ethan; Dueck, Amylou C; Rogak, Lauren J et al. (2017) Feasibility Assessment of Patient Reporting of Symptomatic Adverse Events in Multicenter Cancer Clinical Trials. JAMA Oncol 3:1043-1050
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Hacker, Eileen Danaher; Fink, Anne M; Peters, Tara et al. (2017) Persistent Fatigue in Hematopoietic Stem Cell Transplantation Survivors. Cancer Nurs 40:174-183
Mandelblatt, Jeanne S; Cai, Ling; Luta, George et al. (2017) Frailty and long-term mortality of older breast cancer patients: CALGB 369901 (Alliance). Breast Cancer Res Treat 164:107-117
Himelstein, Andrew L; Foster, Jared C; Khatcheressian, James L et al. (2017) Effect of Longer-Interval vs Standard Dosing of Zoledronic Acid on Skeletal Events in Patients With Bone Metastases: A Randomized Clinical Trial. JAMA 317:48-58
Ji, YongLi; Rounds, Tiffany; Crocker, Abigail et al. (2016) The Effect of Atorvastatin on Breast Cancer Biomarkers in High-Risk Women. Cancer Prev Res (Phila) 9:379-84
Zimmerman, Collin; Atherton, Pamela J; Pachman, Deirdre et al. (2016) MC11C4: a pilot randomized, placebo-controlled, double-blind study of venlafaxine to prevent oxaliplatin-induced neuropathy. Support Care Cancer 24:1071-8

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