This research proposal is designed to enable continued participation in the Primary Breast Cancer Therapy Group --- NSABP. The overall specific aims of the NSABP is to improve disease-free survival in patients with primary operable breast and colorectal cancer. The Hotel-Dieu of Montreal has been an NSABP member since July 1981 and is currently following 141 patients on long-term adjuvant protocols. We expect to increase our new patient accrual to 75 per year. The entry of these patients into the NSABP protocols will enable a more rapid and effective evaluation of current therapeutic regimens and will provide information for the design of future studies. The Hotel-Dieu of Montreal has increased progressively its accrual since the beginning from 16 patients a year to a projected accrual of 58 patients in 9 months in 1985. Furthermore, the principal investigator is a member of the immunology committee of the NSABP for 2 years, and has participated in all the NSABP meetings since 1981. Recent institution evaluation and audits show that Hotel-Dieu of Montreal has made an important effort to increase its accrual and participation to the NSABP.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
5U10CA044066-03
Application #
3558500
Study Section
(SRC)
Project Start
1987-04-15
Project End
1991-01-31
Budget Start
1989-02-01
Budget End
1990-01-31
Support Year
3
Fiscal Year
1989
Total Cost
Indirect Cost
Name
Hotel Dieu de Montreal
Department
Type
DUNS #
City
Montreal
State
PQ
Country
Canada
Zip Code
Bear, Harry D; Tang, Gong; Rastogi, Priya et al. (2017) The Effect on Surgical Complications of Bevacizumab Added to Neoadjuvant Chemotherapy for Breast Cancer: NRG Oncology/NSABP Protocol B-40. Ann Surg Oncol 24:1853-1860
Jatoi, Ismail; Bandos, Hanna; Jeong, Jong-Hyeon et al. (2016) Time-Varying Effects of Breast Cancer Adjuvant Systemic Therapy. J Natl Cancer Inst 108:
Wickerham, D Lawrence; Vogel, Victor G (2015) Breast cancer chemoprevention: the saga of underuse continues. J Natl Cancer Inst 107:399
Bear, Harry D; Tang, Gong; Rastogi, Priya et al. (2015) Neoadjuvant plus adjuvant bevacizumab in early breast cancer (NSABP B-40 [NRG Oncology]): secondary outcomes of a phase 3, randomised controlled trial. Lancet Oncol 16:1037-1048
Swain, Sandra M; Tang, Gong; Geyer Jr, Charles E et al. (2013) Definitive results of a phase III adjuvant trial comparing three chemotherapy regimens in women with operable, node-positive breast cancer: the NSABP B-38 trial. J Clin Oncol 31:3197-204
Bear, Harry D; Tang, Gong; Rastogi, Priya et al. (2012) Bevacizumab added to neoadjuvant chemotherapy for breast cancer. N Engl J Med 366:310-20
Paterson, Alexander H G; Anderson, Stewart J; Lembersky, Barry C et al. (2012) Oral clodronate for adjuvant treatment of operable breast cancer (National Surgical Adjuvant Breast and Bowel Project protocol B-34): a multicentre, placebo-controlled, randomised trial. Lancet Oncol 13:734-42
Krag, David N; Anderson, Stewart J; Julian, Thomas B et al. (2010) Sentinel-lymph-node resection compared with conventional axillary-lymph-node dissection in clinically node-negative patients with breast cancer: overall survival findings from the NSABP B-32 randomised phase 3 trial. Lancet Oncol 11:927-33