The American College of Surgeons Oncology Group (ACOSOG) was established to define the role of surgical therapies in the management of patients with malignant solid tumors. The ACOSOG incorporates general and specialty surgical oncologists as well as non-surgical oncologists, in academic medical centers and community practices throughout the United States of America and foreign countries. This surgical group is important to the oncologic community because of the primary role of surgery in the treatment of patients with cancer. ACOSOG trials will evaluate several areas of surgical and medical oncology. The most important are: a) new and existing operative procedures, b) new technologies and devices, c) clinical studies that are designed for neoadjuvant therapy, d) diagnostic molecular markers and therapeutic biologic agents, e) radiographic imaging procedures and f) interventional therapies in patients diagnosed with certain solid tumors that are less accessible to other cooperative groups. The ACOSOG will participate in trials offered through the Cancer Trials Support Unit (CTSU) when the Group's resources and access to surgical patients can substantially enhance accrual to those trials. ACOSOG benefits from its strong relationship with the American College of Surgeons (ACOS), the largest organization of surgeons in the world, which possesses an extensive geographic membership including general and specialty surgeons in both academic and private practice. Also, the interrelationship of the ACOSOG with the ACOS provides a unique opportunity to utilize the resources of the Cancer Department of the College to develop research and educational programs to support ACOSOG clinical trials. This diverse membership of the ACOS also positions ACOSOG to offer clinical trials to women, minorities and underserved populations. The ACOSOG is committed to lowering cancer incidence and mortality through innovative clinical trials allowing broad physician and patient participation.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
3U10CA076001-11S1
Application #
7496267
Study Section
Subcommittee G - Education (NCI)
Program Officer
Mooney, Margaret M
Project Start
1998-05-15
Project End
2007-11-30
Budget Start
2006-12-01
Budget End
2007-11-30
Support Year
11
Fiscal Year
2007
Total Cost
$300,000
Indirect Cost
Name
Duke University
Department
Surgery
Type
Schools of Medicine
DUNS #
044387793
City
Durham
State
NC
Country
United States
Zip Code
27705
Le-Petross, Huong T; McCall, Linda M; Hunt, Kelly K et al. (2018) Axillary Ultrasound Identifies Residual Nodal Disease After Chemotherapy: Results From the American College of Surgeons Oncology Group Z1071 Trial (Alliance). AJR Am J Roentgenol 210:669-676
Foster, Jared C; Le-Rademacher, Jennifer G; Feliciano, Josephine L et al. (2017) Comparative ""nocebo effects"" in older patients enrolled in cancer therapeutic trials: Observations from a 446-patient cohort. Cancer 123:4193-4198
Brown, Paul D; Ballman, Karla V; Cerhan, Jane H et al. (2017) Postoperative stereotactic radiosurgery compared with whole brain radiotherapy for resected metastatic brain disease (NCCTG N107C/CECĀ·3): a multicentre, randomised, controlled, phase 3 trial. Lancet Oncol 18:1049-1060
Churilla, Thomas M; Ballman, Karla V; Brown, Paul D et al. (2017) Stereotactic Radiosurgery With or Without Whole-Brain Radiation Therapy for Limited Brain Metastases: A Secondary Analysis of the North Central Cancer Treatment Group N0574 (Alliance) Randomized Controlled Trial. Int J Radiat Oncol Biol Phys 99:1173-1178
Ellis, Matthew J; Suman, Vera J; Hoog, Jeremy et al. (2017) Ki67 Proliferation Index as a Tool for Chemotherapy Decisions During and After Neoadjuvant Aromatase Inhibitor Treatment of Breast Cancer: Results From the American College of Surgeons Oncology Group Z1031 Trial (Alliance). J Clin Oncol 35:1061-1069
Singh, Preet Paul; Shi, Qian; Foster, Nathan R et al. (2016) Relationship Between Metformin Use and Recurrence and Survival in Patients With Resected Stage III Colon Cancer Receiving Adjuvant Chemotherapy: Results From North Central Cancer Treatment Group N0147 (Alliance). Oncologist 21:1509-1521
Miller, Christopher A; Gindin, Yevgeniy; Lu, Charles et al. (2016) Aromatase inhibition remodels the clonal architecture of estrogen-receptor-positive breast cancers. Nat Commun 7:12498
Brown, Paul D; Jaeckle, Kurt; Ballman, Karla V et al. (2016) Effect of Radiosurgery Alone vs Radiosurgery With Whole Brain Radiation Therapy on Cognitive Function in Patients With 1 to 3 Brain Metastases: A Randomized Clinical Trial. JAMA 316:401-409
Haffty, Bruce G; McCall, Linda M; Ballman, Karla V et al. (2016) Patterns of Local-Regional Management Following Neoadjuvant Chemotherapy in Breast Cancer: Results From ACOSOG Z1071 (Alliance). Int J Radiat Oncol Biol Phys 94:493-502
Kent, Michael S; Mandrekar, Sumithra J; Landreneau, Rodney et al. (2016) Impact of Sublobar Resection on Pulmonary Function: Long-Term Results from American College of Surgeons Oncology Group Z4032 (Alliance). Ann Thorac Surg 102:230-8

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