Abstract

? This application seeks to continue the H. Lee Moffitt Cancer Center CCOP Research Base for cancer prevention and control studies. The competing continuation grant is proposed from the team of investigators who have more than 20 years experience in a CCOP Research Base, in multi-institutional cancer control and clinical trials and in cancer prevention and control research.
The specific aims of the Research Base are to conduct cancer prevention and control research in the community setting to reduce the burden of cancer on individuals at risk for cancer and to reduce the burden of cancer by improving the quality of life for individuals diagnosed with cancer and their caretakers. Since its inception in June 2000, this Research Base has submitted 17 projects for NCI review. Six of those are actively accruing protocols and 4 more were approved for protocol development. Three protocols are in development, the fourth was not developed due to drug supply issues. Three concepts are currently under review. In addition to these 17 projects, we also conducted a local pilot study and are an intergroup member on MDA 0109, an actively accruing study. Enrollment to these protocols has exceeded expectations, enrolling 107 subjects for a total of 68.5 credits during the initial funding cycle and increasing that to 351 subjects for 218 credits in an additional 13 months. CCOP/MBCCOP enrollments to 200 subjects for 102 credits. The Research Base is currently supported by the membership of 7 CCOPs, 5 MBCCOPs and 3 direct affiliates with an additional 3 under discussion. HLMCC proposes continuing the data management and quality control system that meets Federal regulatory requirements. The H. Lee Moffitt Cancer Center CCOP Research Base complies with DCP/NCI requirements regarding protocol review and monitoring and the terms of the cooperative agreement. We continue our commitment to the recruitment of women and minorities and will seek additional CCOP/MBCCOP affiliates to help us meet this goal. The combination of a strong scientific portfolio, the expertise and experience in the development and implementation of cancer prevention and control protocols in a multi-institutional setting and the strong indication of support from DCP/NCI funded CCOP/MBCCOPs encourages us to believe that we can be successful in meeting our goals. ? ?

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
2U10CA081920-04A1
Application #
6926015
Study Section
Special Emphasis Panel (ZCA1-SRRB-D (J1))
Program Officer
Mccaskill-Stevens, Worta J
Project Start
2000-06-01
Project End
2010-05-31
Budget Start
2005-08-19
Budget End
2006-05-31
Support Year
4
Fiscal Year
2005
Total Cost
$986,002
Indirect Cost

  Institution

Name
University of South Florida
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
069687242
City
Tampa
State
FL
Country
United States
Zip Code
33612

  Publications

Guglin, Maya; Munster, Pamela; Fink, Angelina et al. (2017) Lisinopril or Coreg CR in reducing cardiotoxicity in women with breast cancer receiving trastuzumab: A rationale and design of a randomized clinical trial. Am Heart J 188:87-92
Minasian, Lori M; Tangen, Catherine M; Wickerham, D Lawrence (2015) Ongoing Use of Data and Specimens From National Cancer Institute-Sponsored Cancer Prevention Clinical Trials in the Community Clinical Oncology Program. Semin Oncol 42:748-63
Bradfield, Scott M; Sandler, Eric; Geller, Thomas et al. (2015) Glutamic acid not beneficial for the prevention of vincristine neurotoxicity in children with cancer. Pediatr Blood Cancer 62:1004-10
Couluris, Marisa; Kinder, Brent W; Xu, Ping et al. (2012) Treatment of idiopathic pulmonary fibrosis with losartan: a pilot project. Lung 190:523-7
Munster, Pamela N; Moore, Amy P; Ismail-Khan, Roohi et al. (2012) Randomized trial using gonadotropin-releasing hormone agonist triptorelin for the preservation of ovarian function during (neo)adjuvant chemotherapy for breast cancer. J Clin Oncol 30:533-8
Aguado Loi, Claudia X; Taylor, Teletia R; McMillan, Susan et al. (2012) Use and helpfulness of self-administered stress management therapy in patients undergoing cancer chemotherapy in community clinical settings. J Psychosoc Oncol 30:57-80
Couluris, Marisa; Schnapf, Bruce M; Casey, Allyson et al. (2011) How to measure secondhand smoke exposure in a pediatric clinic setting. Arch Pediatr Adolesc Med 165:670-1
Kumar, Nagi B; Kang, Loveleen; Pow-Sang, Julio et al. (2010) Results of a randomized phase I dose-finding trial of several doses of isoflavones in men with localized prostate cancer: administration prior to radical prostatectomy. J Soc Integr Oncol 8:3-13
Kumar, Nagi B; Besterman-Dahan, Karen; Kang, Loveleen et al. (2008) Results of a Randomized Clinical Trial of the Action of Several Doses of Lycopene in Localized Prostate Cancer: Administration Prior to Radical Prostatectomy. Clin Med Urol 1:1-14
Gross-King, Margaret; Booth-Jones, Margaret; Couluris, Marisa (2008) Neurocognitive impairment in children treated for cancer: how do we measure cognitive outcomes? J Pediatr Oncol Nurs 25:227-32

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