The role of the Administrative core is to coordinate and integrate the multiple components of the ECOG-ACRIN Statistics and Data Management Center (SDMC) and to provide scientific, administrative, and fiscal oversight of SDMC activities. It is also responsible for coordinating collaborations with other NCTN Groups and other research organizations, for coordinating the participation of the SDMC in the collective management of the NCTN, and for ensuring timely provision of data and other resources generated from ECOG-ACRIN projects to the broader scientific community. The SDMC consists of the Biostatistics Center, with personnel at the Dana-Farber Cancer Institute (SDMC-DFCI) and Brown University (SDMC-Brown), and the Data Management Center, with personnel at the ECOG-ACRIN Medical Research Foundation (SDMC-EAMRF) and at the American College of Radiology (SDMC-ACR). The Group Statisticians, Dr. Robert Gray at DFCI and Dr. Constantine Gatsonis at Brown are responsible for all aspects of the SDMC operations. SDMC-DFCI and SDMC- EAMRF are responsible for therapeutic studies, under the leadership of Dr. Gray, and SDMC-Brown and SDMC-ACR are responsible for diagnostic and advanced imaging studies, under the leadership of Dr. Gatsonis. The SDMC components use a common set of Standard Operating Procedures. There are well-established procedures to facilitate communication and coordination among the components and between the SDMC and other ECOG-ACRIN components. The SDMC participates fully in the collective management of the NCTN and has numerous collaborations with other research entities. The SDMC has provided data from ECOG-ACRIN studies to numerous researchers. Going forward, most data sharing will be occurring through the NCTN/NCORP Data Archive, and the SDMC is fully committed to timely submission of data sets from ECOG-ACRIN publications to the Archive. The SDMC is also contributing image libraries to The Cancer Imaging Archive.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
2U10CA180794-06
Application #
9627513
Study Section
Special Emphasis Panel (ZCA1)
Project Start
Project End
Budget Start
2019-04-04
Budget End
2020-02-29
Support Year
6
Fiscal Year
2019
Total Cost
Indirect Cost
Name
Dana-Farber Cancer Institute
Department
Type
DUNS #
076580745
City
Boston
State
MA
Country
United States
Zip Code
02215
Estabrook, Ryne; Cella, David; Zhao, Fengmin et al. (2018) Longitudinal and dynamic measurement invariance of the FACIT-Fatigue scale: an application of the measurement model of derivatives to ECOG-ACRIN study E2805. Qual Life Res 27:1589-1597
Harshman, Lauren C; Chen, Yu-Hui; Liu, Glenn et al. (2018) Seven-Month Prostate-Specific Antigen Is Prognostic in Metastatic Hormone-Sensitive Prostate Cancer Treated With Androgen Deprivation With or Without Docetaxel. J Clin Oncol 36:376-382
Henderson, Tara O; Parsons, Susan K; Wroblewski, Kristen E et al. (2018) Outcomes in adolescents and young adults with Hodgkin lymphoma treated on US cooperative group protocols: An adult intergroup (E2496) and Children's Oncology Group (COG AHOD0031) comparative analysis. Cancer 124:136-144
Dahlberg, Suzanne E; Gray, Robert J (2018) Pragmatic approaches to address expansion cohort design. Cancer 124:3290-3292
Rakovitch, E; Gray, R; Baehner, F L et al. (2018) Refined estimates of local recurrence risks by DCIS score adjusting for clinicopathological features: a combined analysis of ECOG-ACRIN E5194 and Ontario DCIS cohort studies. Breast Cancer Res Treat 169:359-369
Ristau, Benjamin T; Manola, Judi; Haas, Naomi B et al. (2018) Retroperitoneal Lymphadenectomy for High Risk, Nonmetastatic Renal Cell Carcinoma: An Analysis of the ASSURE (ECOG-ACRIN 2805) Adjuvant Trial. J Urol 199:53-59
Wong, Yu-Ning; Manola, Judith; Hudes, Gary R et al. (2018) Phase 2 Study of Weekly Paclitaxel Plus Estramustine in Metastatic Hormone-Refractory Prostate Carcinoma: ECOG-ACRIN Cancer Research Group (E1898) Trial. Clin Genitourin Cancer 16:e315-e322
Scott, David W; King, Rebecca L; Staiger, Annette M et al. (2018) High-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements with diffuse large B-cell lymphoma morphology. Blood 131:2060-2064
Ailawadhi, Sikander; Jacobus, Susanna; Sexton, Rachael et al. (2018) Disease and outcome disparities in multiple myeloma: exploring the role of race/ethnicity in the Cooperative Group clinical trials. Blood Cancer J 8:67
Morgans, Alicia K; Chen, Yu-Hui; Sweeney, Christopher J et al. (2018) Quality of Life During Treatment With Chemohormonal Therapy: Analysis of E3805 Chemohormonal Androgen Ablation Randomized Trial in Prostate Cancer. J Clin Oncol 36:1088-1095

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