Administrative Core The SWOG SDMC Administrative Core is the home of the senior administrative leadership team of the SDMC; it provides integration between the statistics and data management components. The senior administrative team (in partnership with the SWOG Group Chair and NCI) sets priorities regarding the development of clinical trial designs, monitoring, and data management for SWOG within the NCTN. The SWOG SDMC is located at the Fred Hutchinson Cancer Research Center and Cancer Research And Biostatistics, which are both non-profit research organizations. The SDMC contributes to the collective management of the NCTN Program by participating in the NCI Scientific Steering Committees, associated Task Forces, Working Groups, and other NCI initiatives. In addition, the Administrative Core provides data from completed clinical trials in a timely and user-friendly format for public access. The staff help in the interpretation of clinical data and facilitate the approved use of NCTN program specimens archived by SWOG at the centralized biobank at Children's Nationwide Hospital. SDMC faculty and staff have extensive collaborations with other NCTN Network Groups for the design, conduct, and analysis of clinical trials. They also have significant collaborations with other NCI-sponsored programs, especially the NCORP program. The faculty contribute to new statistical methods developments for clinical trials design, data monitoring and analysis, and genomic analysis, which is useful within the NCTN and also widely applicable to the greater cancer research community. Areas of interest include new methods for precision medicine, immunotherapy studies, and high-dimensional data analysis.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Cooperative Clinical Research--Cooperative Agreements (U10)
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Special Emphasis Panel (ZCA1)
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Fred Hutchinson Cancer Research Center
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Rimsza, Lisa M; Li, Hongli; Braziel, Rita M et al. (2018) Impact of histological grading on survival in the SWOG S0016 follicular lymphoma cohort. Haematologica 103:e151-e153
Dai, James Y; Liang, C Jason; LeBlanc, Michael et al. (2018) Case-only approach to identifying markers predicting treatment effects on the relative risk scale. Biometrics 74:753-763
Sharma, P; Barlow, W E; Godwin, A K et al. (2018) Impact of homologous recombination deficiency biomarkers on outcomes in patients with triple-negative breast cancer treated with adjuvant doxorubicin and cyclophosphamide (SWOG S9313). Ann Oncol 29:654-660
Zhan, Xiang; Wu, Michael C (2018) Reader Reaction: A note on testing and estimation in marker-set association study using semiparametric quantile regression kernel machine. Biometrics 74:764-766
Mongiovi, Jennifer M; Zirpoli, Gary R; Cannioto, Rikki et al. (2018) Associations between self-reported diet during treatment and chemotherapy-induced peripheral neuropathy in a cooperative group trial (S0221). Breast Cancer Res 20:146
Halpern, Anna B; Othus, Megan; Huebner, Emily M et al. (2018) Phase 1/2 trial of GCLAM with dose-escalated mitoxantrone for newly diagnosed AML or other high-grade myeloid neoplasms. Leukemia :
Messing, Edward M; Tangen, Catherine M; Lerner, Seth P et al. (2018) Effect of Intravesical Instillation of Gemcitabine vs Saline Immediately Following Resection of Suspected Low-Grade Non-Muscle-Invasive Bladder Cancer on Tumor Recurrence: SWOG S0337 Randomized Clinical Trial. JAMA 319:1880-1888
Smith, Eileen P; Li, Hongli; Friedberg, Jonathan W et al. (2018) Tandem Autologous Hematopoietic Cell Transplantation for Patients with Primary Progressive or Recurrent Hodgkin Lymphoma: A SWOG and Blood and Marrow Transplant Clinical Trials Network Phase II Trial (SWOG S0410/BMT CTN 0703). Biol Blood Marrow Transplant 24:700-707
Unger, Joseph M; Vaidya, Riha; Gore, John L (2018) Key design and analysis principles for quality of life and patient-reported outcomes in clinical trials. Urol Oncol :
Cheng, Ting-Yuan David; Darke, Amy K; Redman, Mary W et al. (2018) Smoking, Sex, and Non-Small Cell Lung Cancer: Steroid Hormone Receptors in Tumor Tissue (S0424). J Natl Cancer Inst 110:734-742

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