(Applicant?s Abstract) The Collaborative Longitudinal Evaluation of Ethnicity and Refractive Error (CLEERE) Study is an expansion of the Orinda. Longitudinal Study of Myopia (OLSM). The original, single-center study started in Orinda, California in 1989, and the three CLEERE clinics were added during its second phase of funding in 1997. Data on refractive error and the ocular components have been gathered on 1,504 children in Orinda. (90 percent Caucasian), and the expansion to sites in Alabama, Texas, and southern California was motivated by an interest in including African-American, Hispanic, and Asian children. This eight-year lag will result in 11 consecutive years of follow-up data from the Caucasian children and only three years of follow data from the other ethnic groups. Thus, we propose to continue the study at three of the current sites and to terminate the follow-up of children in Orinda. By academic year 2005-06, we will have longitudinal data across eight years for all children, which will enable meaningful comparisons about ocular growth and refractive development as a function of ethnicity. Additionally, we will establish the representativeness of our sample of convenience in Alabama, Texas, and southern California. Participation rates in the CLEERE Study range from 15 percent to 56 percent at these three sites. We propose an annual vision screening of all kindergartners, second, and fifth graders (kindergartners, third, and sixth graders in southern California) in the relevant school districts that participate in the CLEERE Study at the three sites to compare the age and refractive error distributions in participants versus non-participants. We have assembled a database of DNA from 65 Orinda-based myopic children and their families at the University of Iowa. We will continue DNA-based studies on the prevalent OLSM myopes and their families to use these phenotypically well-characterized children and a panel of candidate genes to look for evidence of genetic factors. In parallel with the candidate gene association, family material will be used in an allele sharing approach to identify loci using highly variable, PCR-based markers. We will add this phase to the southern California site for Asian families and to the Alabama site for African-American families. We will continue to examine children in grades I through 8 (ages 6 through 14 years) annually. The measurement of refractive error, the ocular components, accommodative response, accommodative lag, phoria, response AC/A ratio, peripheral refractive error, pushup accommodative amplitude, and intraocular pressure will be performed.
| Haworth, Kristina M; Chandler, Heather L (2017) Seasonal Effect on Ocular Sun Exposure and Conjunctival UV Autofluorescence. Optom Vis Sci 94:219-228 |
| Haworth, Kristina M; Chandler, Heather L (2017) Oxidative Stress Measures of Lipid and DNA Damage in Human Tears. Invest Ophthalmol Vis Sci 58:BIO151-BIO157 |
| Mutti, Donald O; Mitchell, G Lynn; Jones-Jordan, Lisa A et al. (2017) The Response AC/A Ratio Before and After the Onset of Myopia. Invest Ophthalmol Vis Sci 58:1594-1602 |
| Zadnik, Karla; Mutti, Donald O (2015) Who Says There's Nothing New under the Sun? Optom Vis Sci 92:e392-3 |
| Zadnik, Karla; Sinnott, Loraine T; Cotter, Susan A et al. (2015) Prediction of Juvenile-Onset Myopia. JAMA Ophthalmol 133:683-9 |
| Harvey, Erin M; Miller, Joseph M; Twelker, J Daniel et al. (2015) Longitudinal change and stability of refractive, keratometric, and internal astigmatism in childhood. Invest Ophthalmol Vis Sci 56:190-8 |
| Jones-Jordan, Lisa A; Sinnott, Loraine T; Graham, Nicholas D et al. (2014) The contributions of near work and outdoor activity to the correlation between siblings in the Collaborative Longitudinal Evaluation of Ethnicity and Refractive Error (CLEERE) Study. Invest Ophthalmol Vis Sci 55:6333-9 |
| Pucker, Andrew D; Carpenter, Ashley R; McHugh, Kirk M et al. (2014) Guinea pig ciliary muscle development. Optom Vis Sci 91:730-9 |
| Twelker, J Daniel; Miller, Joseph M; Sherrill, Duane L et al. (2013) Astigmatism and myopia in Tohono O'odham Native American children. Optom Vis Sci 90:1267-73 |
| Richdale, Kathryn; Sinnott, Loraine T; Bullimore, Mark A et al. (2013) Quantification of age-related and per diopter accommodative changes of the lens and ciliary muscle in the emmetropic human eye. Invest Ophthalmol Vis Sci 54:1095-105 |
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