Numerous epidemiologic studies have provided estimates of the prevalence of cataract, glaucoma, diabetic retinopathy and age-related maculopathy, blindness and visual impairment among Whites and Blacks in the United States. No similar quality data exists on Latinos in the United States - the fastest growing racial/ethnic group and projected to be the largest minority by the year 2005. To help assess the needs for eye care in the United States, such data are crucial. The Los Angeles Latino Eye Study (LALES) will determine the prevalence in Latinos in urban Los Angeles of cataract, glaucoma, age-related maculopathy, diabetic retinopathy, and cause-specific rates of blindness and visual impairment. The LALES will also explore the association of various risk factors with ocular disease. In addition, the LALES will study the effect of ocular disease on quality of life and utilization of eye care services and determine the cost-benefit of eye care services and the utility of eye health. All Latinos aged 40 years or older in six contiguous census tracts in the City of La Puente in Los Angeles County will be included in the study. Each individual will undergo an interview and a screening eye examination. This includes a measurement of height, weight, blood pressure, visual acuity, visual field, intraocular pressure, glycosylated hemoglobin, random blood glucose and lens, optic disc and fundus photography. Individuals with abnormal or unreliable measurements will undergo a definitive eye examination by an ophthalmologist. Data from these evaluations will allow us to determine the prevalence of and risk factors associated with ocular disease, blindness, and visual impairment. The study methodology and design will also allow comparison to previously obtained prevalence and risk factor data in Whites and Blacks. Additionally, we will be able to evaluate the effect of ocular disease on the quality of life and visual functioning of the participants, the utility of eye health and determine the utilization of eye care services.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
5U10EY011753-05
Application #
6524933
Study Section
Special Emphasis Panel (ZEY1-VSN (01))
Program Officer
Kurinij, Natalie
Project Start
1998-09-30
Project End
2003-09-29
Budget Start
2002-09-30
Budget End
2003-09-29
Support Year
5
Fiscal Year
2002
Total Cost
$1,931,937
Indirect Cost
Name
University of Southern California
Department
Ophthalmology
Type
Schools of Medicine
DUNS #
041544081
City
Los Angeles
State
CA
Country
United States
Zip Code
90089
Jiang, Xuejuan; Torres, Mina; Varma, Rohit et al. (2018) Variation in Intraocular Pressure and the Risk of Developing Open-Angle Glaucoma: The Los Angeles Latino Eye Study. Am J Ophthalmol 188:51-59
Nannini, Drew R; Torres, Mina; Chen, Yii-Der I et al. (2017) A Genome-Wide Association Study of Vertical Cup-Disc Ratio in a Latino Population. Invest Ophthalmol Vis Sci 58:87-95
Nannini, Drew; Torres, Mina; Chen, Yii-Der I et al. (2016) Reply. Ophthalmology 123:e31-2
Choudhury, Farzana; Varma, Rohit; Klein, Ronald et al. (2016) Age-Related Macular Degeneration and Quality of Life in Latinos: The Los Angeles Latino Eye Study. JAMA Ophthalmol 134:683-90
Gao, Xiaoyi; Nannini, Drew R; Corrao, Kristen et al. (2016) Genome-wide association study identifies WNT7B as a novel locus for central corneal thickness in Latinos. Hum Mol Genet 25:5035-5045
Nannini, Drew; Torres, Mina; Chen, Yii-Der I et al. (2016) African Ancestry Is Associated with Higher Intraocular Pressure in Latinos. Ophthalmology 123:102-8
Palmer, Nicholette D; Goodarzi, Mark O; Langefeld, Carl D et al. (2015) Genetic Variants Associated With Quantitative Glucose Homeostasis Traits Translate to Type 2 Diabetes in Mexican Americans: The GUARDIAN (Genetics Underlying Diabetes in Hispanics) Consortium. Diabetes 64:1853-66
Otilingam, Poorni G; Gatz, Margaret; Tello, Elizabeth et al. (2015) Buenos hábitos alimenticios para una buena salud : evaluation of a nutrition education program to improve heart health and brain health in Latinas. J Aging Health 27:177-92
Klein, Ronald; Meuer, Stacy M; Myers, Chelsea E et al. (2014) Harmonizing the classification of age-related macular degeneration in the three-continent AMD consortium. Ophthalmic Epidemiol 21:14-23
Kashani, Amir H; Lopez Jaime, Gilberto R; Saati, Saloomeh et al. (2014) Noninvasive assessment of retinal vascular oxygen content among normal and diabetic human subjects: a study using hyperspectral computed tomographic imaging spectroscopy. Retina 34:1854-60

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