The current proposal provides a unique opportunity to investigate the development of eye disease in a population-based study ofthe largest minority group in the United States and to examine novel lifestyle, biologic and genetic hypotheses related to the risk of developing these diseases. The study is designed to capture the 8-year incidence ofthe major vision-threatening eye diseases in Latinos (Mexican-Americans), including early age-related maculopathy (ARM), diabetic retinopathy (DR), and open-angle glaucoma (OAG), and the impact of these diseases on visual function. This application builds on the knowledge gained from the Los Angeles Latino Eye Study (TALES), a population-based study of 6,357 Mexican-Americans aged 40 years and older. The cohort was assembled by recruiting Latino adults residing in 6 census tracts in Los Angeles County with clinical eye examinations given in 2000-2003 and re-examinations in 2004-2008. The data obtainedfromthis study have been used to document the prevalence, incidence, and impact of visual impairment, ARM, DR, and OAG over a 4-year period. In this application, we propose to re-examine the LALES cohort 8 years after the baseline examination. The additional incident cases that will be collected through 8 years of follow up will be needed for (i) biological and behavioral risk factor analyses, including time-dependent covariates assessed at baseline and follow-up (ii) replication offindingsfrom cross-sectional (prevalent) analyses using incident data while avoiding issues of temporality that can be of concem when exposure history or quality of life data is collected after disease is diagnosed and (iii) genetic analyses for a genome-wide association study (GWAS) of DR and early ARM.

National Institute of Health (NIH)
National Eye Institute (NEI)
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
Application #
Study Section
Special Emphasis Panel (ZEY1-VSN (02))
Program Officer
Wideroff, Louise
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Illinois at Chicago
Schools of Medicine
United States
Zip Code
Jiang, Xuejuan; Torres, Mina; Varma, Rohit et al. (2018) Variation in Intraocular Pressure and the Risk of Developing Open-Angle Glaucoma: The Los Angeles Latino Eye Study. Am J Ophthalmol 188:51-59
Nannini, Drew R; Torres, Mina; Chen, Yii-Der I et al. (2017) A Genome-Wide Association Study of Vertical Cup-Disc Ratio in a Latino Population. Invest Ophthalmol Vis Sci 58:87-95
Nannini, Drew; Torres, Mina; Chen, Yii-Der I et al. (2016) Reply. Ophthalmology 123:e31-2
Choudhury, Farzana; Varma, Rohit; Klein, Ronald et al. (2016) Age-Related Macular Degeneration and Quality of Life in Latinos: The Los Angeles Latino Eye Study. JAMA Ophthalmol 134:683-90
Gao, Xiaoyi; Nannini, Drew R; Corrao, Kristen et al. (2016) Genome-wide association study identifies WNT7B as a novel locus for central corneal thickness in Latinos. Hum Mol Genet 25:5035-5045
Nannini, Drew; Torres, Mina; Chen, Yii-Der I et al. (2016) African Ancestry Is Associated with Higher Intraocular Pressure in Latinos. Ophthalmology 123:102-8
Palmer, Nicholette D; Goodarzi, Mark O; Langefeld, Carl D et al. (2015) Genetic Variants Associated With Quantitative Glucose Homeostasis Traits Translate to Type 2 Diabetes in Mexican Americans: The GUARDIAN (Genetics Underlying Diabetes in Hispanics) Consortium. Diabetes 64:1853-66
Otilingam, Poorni G; Gatz, Margaret; Tello, Elizabeth et al. (2015) Buenos hábitos alimenticios para una buena salud : evaluation of a nutrition education program to improve heart health and brain health in Latinas. J Aging Health 27:177-92
Klein, Ronald; Meuer, Stacy M; Myers, Chelsea E et al. (2014) Harmonizing the classification of age-related macular degeneration in the three-continent AMD consortium. Ophthalmic Epidemiol 21:14-23
Kashani, Amir H; Lopez Jaime, Gilberto R; Saati, Saloomeh et al. (2014) Noninvasive assessment of retinal vascular oxygen content among normal and diabetic human subjects: a study using hyperspectral computed tomographic imaging spectroscopy. Retina 34:1854-60

Showing the most recent 10 out of 60 publications