This proposal is for the Pennsylvania College of Optometry Clinical Center to continue to annually examine the 93 currently enrolled COSMICC participants (only 15 subjects have been lost to follow-up since enrolled in 1997-98) at the Pennsylvania College of Optometry center for an additional 5 yrs (total follow-up, 14 yrs) following the COSMICC2 protocol. The data collected from this center will be used to address the specific aims described in more detail in the Chair application and summarized briefly here: 1) to use mathematical functions (the Gompertz function and others) to model myopia progression in the 58% of COSMICC subjects with progressing myopia and to develop predictive models and test hypotheses based on previously identified risk factors (age, ethnicity, parental myopia);2) to test 4 hypotheses related to environmental risk factors for myopia progression and stabilization and axial elongation in this well-characterized cohort of myopes;and 3) to test three hypotheses related to risk factors for the development of myopia-related changes in IOP, CCT and macular thickness in COSMICC subjects. The high prevalence of myopia (25% of the US adult population) and its prominence as a public health problem (risk factor for conditions that can cause vision loss and blindness) emphasize the importance of gaining increased understanding of mechanisms underlying progression and eventual stabilization, so that in the future myopia might be limited to low levels. Better understanding of the factors predictive of myopia progression and stabilization also will help guide selection and timing of interventions as well as target those groups that may benefit the most from treatment. This application documents the Pennsylvania College of Optometry's ability to follow the COSMICC2 Manual of Procedures and to retain patients for five years. Documentation is also provided that the Pennsylvania College of Optometry has the personnel, equipment, and facilities to conduct the study in accordance with the COSMICC2 Manual of Procedures.

National Institute of Health (NIH)
National Eye Institute (NEI)
Cooperative Clinical Research--Cooperative Agreements (U10)
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Application #
Study Section
Special Emphasis Panel (ZEY1-VSN (05))
Program Officer
Everett, Donald F
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Salus University
Schools of Optometry/Ophthalmol
Elkins Park
United States
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Scheiman, Mitchell M (2018) 2017 Glenn A. Fry Award Lecture: Establishing an Evidence-based Literature for Vision Therapy - A 25-year Journey. Optom Vis Sci 95:632-642
Hou, Wei; Norton, Thomas T; Hyman, Leslie et al. (2018) Axial Elongation in Myopic Children and its Association With Myopia Progression in the Correction of Myopia Evaluation Trial. Eye Contact Lens 44:248-259
Liu, Lei; Marsh-Tootle, Wendy; Harb, Elise N et al. (2016) A sloped piecemeal Gaussian model for characterising foveal pit shape. Ophthalmic Physiol Opt 36:615-631
Scheiman, Mitchell; Gwiazda, Jane; Zhang, Qinghua et al. (2016) Longitudinal changes in corneal curvature and its relationship to axial length in the Correction of Myopia Evaluation Trial (COMET) cohort. J Optom 9:13-21
Manny, Ruth E; Deng, Li; Gwiazda, Jane et al. (2016) Internal Astigmatism in Myopes and Non-myopes: Compensation or Constant? Optom Vis Sci 93:1079-92
Harb, Elise; Hyman, Leslie; Gwiazda, Jane et al. (2015) Choroidal Thickness Profiles in Myopic Eyes of Young Adults in the Correction of Myopia Evaluation Trial Cohort. Am J Ophthalmol 160:62-71.e2
Scheiman, Mitchell; Zhang, Qinghua; Gwiazda, Jane et al. (2014) Visual activity and its association with myopia stabilisation. Ophthalmic Physiol Opt 34:353-61
Gwiazda, Jane; Deng, Li; Manny, Ruth et al. (2014) Seasonal variations in the progression of myopia in children enrolled in the correction of myopia evaluation trial. Invest Ophthalmol Vis Sci 55:752-8
Deng, Li; Gwiazda, Jane; Manny, Ruth E et al. (2014) Limited change in anisometropia and aniso-axial length over 13 years in myopic children enrolled in the Correction of Myopia Evaluation Trial. Invest Ophthalmol Vis Sci 55:2097-105
Dias, Lynette; Manny, Ruth E; Weissberg, Erik et al. (2013) Myopia, contact lens use and self-esteem. Ophthalmic Physiol Opt 33:573-80

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