Intraocular lenses (lOLs) are now the accepted treatment following cataract surgery in older children and are being used increasingly in younger children and infants, but little is known about the safety or efficacy of lOLs for a rapidly growing eye. The objective of the Infant Aphakia Treatment Study (lATS) is to compare the relative efficacy and safety of lOL correction versus contact lens correction in infants with a unilateral congenital cataract removed between the ages of 1 to 7 months. The primary outcome of the clinical trial is visual acuity. We enrolled 114 patients in lATS between December 2004 and January 2009. Phase 1 of the lATS involved following all patients to one year of age so that grating acuity could be assessed with Teller Acuity cards and was completed in January 2010. Phase 2 of lATS involved following all patients to 5 years of age and assessing optotype acuity with the HOTV test at age 4 !4 years. We are now requesting additional funding to perform one more clinical examination of these patients at age 10 years so that the following factors can be compared between the two treatment groups: 1) the primary outcome, visual acuity using the E-ETDRS logMAR chart;and 2) the incidence of glaucoma after a longer-term follow-up. The public health importance of this clinical trial not only impacts the approximately 400 children born each year in the United States with a unilateral congenital cataract, but also the 200,000 children worldwide who are blind from cataracts. lATS is funded through two grants, one for the Chairman's Office (U10 EY013272, Scott Lambert, PI) and one for the Data Coordinating Center (U10 EY013287, Michael Lynn, PI).

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National Institute of Health (NIH)
National Eye Institute (NEI)
Cooperative Clinical Research--Cooperative Agreements (U10)
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Special Emphasis Panel (ZEY1-VSN (03))
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Everett, Donald F
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Emory University
Schools of Medicine
United States
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Koo, Euna B; VanderVeen, Deborah K; Lambert, Scott R (2018) Global Practice Patterns in the Management of Infantile Cataracts. Eye Contact Lens 44 Suppl 2:S292-S296
Cromelin, Caroline H; Drews-Botsch, Carolyn; Russell, Buddy et al. (2018) Association of Contact Lens Adherence With Visual Outcome in the Infant Aphakia Treatment Study: A Secondary Analysis of a Randomized Clinical Trial. JAMA Ophthalmol 136:279-285
Weakley Jr, David R; Lynn, Michael J; Dubois, Lindreth et al. (2017) Myopic Shift 5 Years after Intraocular Lens Implantation in the Infant Aphakia Treatment Study. Ophthalmology 124:822-827
Traboulsi, Elias I; Freedman, Sharon F; Wilson Jr, M Edward et al. (2017) Cataract morphology and risk for glaucoma after cataract surgery in infants with unilateral congenital cataract. J Cataract Refract Surg 43:1611-1612
Russell, Buddy; DuBois, Lindreth; Lynn, Michael et al. (2017) The Infant Aphakia Treatment Study Contact Lens Experience to Age 5 Years. Eye Contact Lens 43:352-357
Weakley, David; Cotsonis, George; Wilson, M Edward et al. (2017) Anisometropia at Age 5 Years After Unilateral Intraocular Lens Implantation During Infancy in the Infant Aphakia Treatment Study. Am J Ophthalmol 180:1-7
Wilson, M Edward; Trivedi, Rupal H; Weakley Jr, David R et al. (2017) Globe Axial Length Growth at Age 5 Years in the Infant Aphakia Treatment Study. Ophthalmology 124:730-733
Bothun, Erick D; Lynn, Michael J; Christiansen, Stephen P et al. (2016) Strabismus surgery outcomes in the Infant Aphakia Treatment Study (IATS) at age 5 years. J AAPOS 20:501-505
Lambert, Scott R; Cotsonis, George; DuBois, Lindreth et al. (2016) Comparison of the rate of refractive growth in aphakic eyes versus pseudophakic eyes in the Infant Aphakia Treatment Study. J Cataract Refract Surg 42:1768-1773
Lambert, Scott R (2016) The timing of surgery for congenital cataracts: Minimizing the risk of glaucoma following cataract surgery while optimizing the visual outcome. J AAPOS 20:191-2

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