This continuation application demonstrates all the necessary elements for our Center to remain a Network member. The extensive publication record provides unequivocal evidence of sustained productivity both within and beyond the Network. Our ability to design protocols, recruit patients, analyze and interpret data and effectively collaborate with other Network centers, the Data Center, and NIH is evident. There are 11 Board certified academic neonatologists permitting protected time for Network activities by investigators. Over 1000 newborns, including approximately 200 with birthweight <1.5 kg, are admitted annually. The obstetric service, including many high risk patients, will exceed 5000 deliveries this year. Four Maternal-Fetal specialists with interest in clinical research and committed to the Network are on staff. Our State Designated Level III perinatal Center includes state-of-the-art facilities for Neonatal Intensive Care and the newly constructed labor and delivery suites have central fetal monitoring. There is a full complement of pediatric medical and surgical subspecialists together with strong nationally recognized programs in respiratory therapy, nursing, genetics, nutrition, radiology, pediatric pathology, and pharmacy. There are an array of laboratories including biochemistry, hematology, immunology and microbiology, and a full service blood bank. The Radiology Department is replete with facilities for standard radiography, ultrasound, CT scanning, HRI and MR angiography, plus PET scanners. Our follow-up program is nationally acclaimed and boasts in excess of an 85% follow-up rate. The established computerized neonatal/ perinatal and follow-up data systems have supported a number of studies. We maintain timely and accurate transmission of data to the Data Center. The experienced nurse coordinator and clinical research nurse team ensure high enrollment rates and strict compliance with protocols. There is a firm divisional, departmental and institutional commitment to participate in a collaborative manner with other centers. CWRU has performed with distinction and is strongly desirous of continued participation in the Network. We accept the budgetary process. In summary, we once again satisfy all criteria for selection into the Network. We have documented a resolute intention to participate, a broad patient base, outstanding facilities, committed experienced personnel, computerized neonatal/ perinatal database, firm institutional backing, academic productivity, and the ability to collaborate well with our Network colleagues, hence satisfying all Network selection criteria.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
5U10HD021364-15
Application #
6181494
Study Section
Special Emphasis Panel (SRC (NN))
Program Officer
Wright, Linda
Project Start
1986-04-01
Project End
2001-03-31
Budget Start
2000-04-01
Budget End
2001-03-31
Support Year
15
Fiscal Year
2000
Total Cost
$320,727
Indirect Cost
Name
Case Western Reserve University
Department
Pediatrics
Type
Schools of Medicine
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
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Natarajan, Girija; Shankaran, Seetha; Laptook, Abbot R et al. (2018) Association between sedation-analgesia and neurodevelopment outcomes in neonatal hypoxic-ischemic encephalopathy. J Perinatol 38:1060-1067
Hintz, Susan R; Vohr, Betty R; Bann, Carla M et al. (2018) Preterm Neuroimaging and School-Age Cognitive Outcomes. Pediatrics 142:
Vohr, Betty R; Heyne, Roy; Bann, Carla M et al. (2018) Extreme Preterm Infant Rates of Overweight and Obesity at School Age in the SUPPORT Neuroimaging and Neurodevelopmental Outcomes Cohort. J Pediatr 200:132-139.e3
Askie, Lisa M; Darlow, Brian A; Finer, Neil et al. (2018) Association Between Oxygen Saturation Targeting and Death or Disability in Extremely Preterm Infants in the Neonatal Oxygenation Prospective Meta-analysis Collaboration. JAMA 319:2190-2201
Chawla, Sanjay; Natarajan, Girija; Chowdhury, Dhuly et al. (2018) Neonatal Morbidities among Moderately Preterm Infants with and without Exposure to Antenatal Corticosteroids. Am J Perinatol 35:1213-1221
Brumbaugh, Jane E; Colaizy, Tarah T; Saha, Shampa et al. (2018) Oral feeding practices and discharge timing for moderately preterm infants. Early Hum Dev 120:46-52
Natarajan, Girija; Shankaran, Seetha; Saha, Shampa et al. (2018) Antecedents and Outcomes of Abnormal Cranial Imaging in Moderately Preterm Infants. J Pediatr 195:66-72.e3
Jilling, Tamas; Ambalavanan, Namasivayam; Cotten, C Michael et al. (2018) Surgical necrotizing enterocolitis in extremely premature neonates is associated with genetic variations in an intergenic region of chromosome 8. Pediatr Res 83:943-953
Srinivasan, Lakshmi; Page, Grier; Kirpalani, Haresh et al. (2017) Genome-wide association study of sepsis in extremely premature infants. Arch Dis Child Fetal Neonatal Ed 102:F439-F445

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